{"id":"W4413345515","doi":"10.1038/s41586-025-09370-8","title":"Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy","year":2025,"lang":"en","type":"article","venue":"Nature","topic":"Cancer, Stress, Anesthesia, and Immune Response","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Center for Advancing Translational Sciences; National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Cancer Institute","keywords":"Cancer; Cancer therapy; Medicine; Resistance (ecology); Cancer research; Internal medicine; Biology; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001627824,0.0002085914,0.0004032448,0.0002015397,0.000111318,0.00003368096,0.0001786794,0.0007243532,0.00009148233],"category_scores_gemma":[0.0001857983,0.000168653,0.0001324266,0.0006947517,0.00003890697,0.00006068106,0.00002976732,0.001266443,0.00001421595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001476756,"about_ca_system_score_gemma":0.0005078879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001522439,"about_ca_topic_score_gemma":0.0001362974,"domain_scores_codex":[0.9987807,0.0000601428,0.0002151983,0.0003687444,0.0002672499,0.0003080027],"domain_scores_gemma":[0.9990718,0.00006782516,0.00006177395,0.0005152814,0.0001856125,0.00009764838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0129964,0.0004159607,0.01490695,0.0005162489,0.0003797725,0.0001627255,0.001091475,0.000002049315,0.4787058,0.0009903817,0.3363591,0.1534732],"study_design_scores_gemma":[0.001234114,0.0002185798,0.1435203,0.0008226902,0.00004318395,0.000008035391,0.00007143518,0.000003900435,0.232872,0.00007797353,0.6209283,0.0001994535],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9401841,0.02798969,0.000003627374,0.02751545,0.0007374597,0.0006891531,0.00002332918,0.0001111088,0.002746104],"genre_scores_gemma":[0.9744864,0.001330821,0.0001501456,0.007241859,0.0005680427,0.00009119775,0.00001119612,0.0000288436,0.01609157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2845693,"threshold_uncertainty_score":0.6877471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0105667730592202,"score_gpt":0.320050670461195,"score_spread":0.3094838974019748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}