{"id":"W4413345796","doi":"10.1186/s12885-025-14789-3","title":"A SORT1/EGFR molecular interplay as a prognostic biomarker in glioblastoma vasculogenic mimicry: implications in the transcriptional regulation of cancer stemness and drug resistance","year":2025,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Cancer stem cell; Cancer research; Biology; Epidermal growth factor receptor; Cancer; Exosome; Stem cell; microRNA; Microvesicles; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002166521,0.0001266936,0.0001299087,0.0001041275,0.00003455487,0.00001575536,0.0002082964,0.00008248536,0.00002128078],"category_scores_gemma":[0.00005820267,0.0001139917,0.00007694363,0.0003467956,0.0001306728,0.000007165529,0.00004291853,0.00007131667,4.254895e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005771605,"about_ca_system_score_gemma":0.0003046932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001938123,"about_ca_topic_score_gemma":0.01371471,"domain_scores_codex":[0.9989495,0.0001510349,0.0002832256,0.0003388071,0.0001132326,0.0001642305],"domain_scores_gemma":[0.9994662,0.00003580522,0.00008108309,0.0003182256,0.00007030065,0.00002839386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004661246,0.0001273966,0.09687006,0.0002095667,0.00005919154,0.000002049036,0.0002253605,0.0002632921,0.89777,0.002267107,0.0004310219,0.001308791],"study_design_scores_gemma":[0.001366759,0.00002412947,0.9088873,0.0003926019,0.00009619865,0.000003530822,0.0001710524,0.0002200517,0.08285253,0.001757153,0.004018649,0.0002100477],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9752564,0.02185807,0.001265976,0.0007442559,0.00005730682,0.0005447608,0.00005846111,0.000004834828,0.0002099372],"genre_scores_gemma":[0.9980279,0.000310047,0.0001772263,0.0002189263,0.00001593529,0.0006961541,0.00002554124,0.00001281308,0.0005154475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8149175,"threshold_uncertainty_score":0.765313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007652683287412555,"score_gpt":0.2962708958592299,"score_spread":0.2886182125718174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}