{"id":"W4413358799","doi":"10.1111/dom.16652","title":"Binding kinetics, bias, receptor internalization and effects on insulin secretion in vitro and in vivo of a novel <scp>GLP</scp> ‐ <scp>1R</scp> / <scp>GIPR</scp> dual agonist, <scp>HISHS</scp> ‐2001","year":2025,"lang":"en","type":"article","venue":"Diabetes Obesity and Metabolism","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Centre Hospitalier de l’Université de Montréal","funders":"Division of Diabetes, Endocrinology, and Metabolic Diseases; Institute of Nutrition, Metabolism and Diabetes; National Institute of Diabetes and Digestive and Kidney Diseases; Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Eli Lilly and Company; Society for Endocrinology; Diabetes UK; Wellcome Trust; Canada Foundation for Innovation","keywords":"Receptor; Incretin; Agonist; Internalization; Internal medicine; Endocrinology; G protein-coupled receptor; Insulin; In vivo; Downregulation and upregulation; Glucagon-like peptide-1; Medicine; Glucagon-like peptide 1 receptor; Type 2 diabetes; Pharmacology; Diabetes mellitus; Chemistry; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002593473,0.0002348078,0.0001669133,0.00009791025,0.00009535361,0.0002169462,0.0001806016,0.0002536359,0.001071899],"category_scores_gemma":[0.0001905118,0.0001548776,0.0001595128,0.000123444,0.0001318603,0.0001495847,0.00007044029,0.0003640854,0.0003862978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003163099,"about_ca_system_score_gemma":0.000125526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005023922,"about_ca_topic_score_gemma":0.000411009,"domain_scores_codex":[0.9998264,0.00004909136,0.00001723111,0.00002977008,0.00004190846,0.00003557301],"domain_scores_gemma":[0.999854,0.00006059413,0.00003353287,0.00001571991,0.00001477401,0.00002141297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002841856,0.00003581692,0.00006576748,0.0000253301,0.000004936335,0.00002246649,0.00001277135,0.000179701,0.9984353,0.00005059196,0.00003429787,0.0008487762],"study_design_scores_gemma":[0.00002158605,0.0006828099,0.001163803,0.000002645304,0.00001000369,0.0001065731,0.00001312747,0.001258684,0.9960418,0.000009472502,0.0006842763,0.000005298649],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969637,0.0005653653,0.001296177,0.00004043685,0.000009515754,0.00002232658,0.0002251215,0.0000179485,0.0008595387],"genre_scores_gemma":[0.9923108,0.0007403737,0.002883959,0.00005434121,0.000008348648,0.00003618676,0.0006570511,0.00001539138,0.003293603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001071899,"threshold_uncertainty_score":0.003585875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01166022175055683,"score_gpt":0.2336599510045484,"score_spread":0.2219997292539916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}