{"id":"W4413361839","doi":"10.1038/s41392-026-02623-6","title":"Rapid CAR screening and circRNA-driven CAR-NK cells for persistent shed-resistant immunotherapy","year":2025,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; University of Ottawa","funders":"Seoul National University Hospital; National Research Foundation of Korea; Korea Institute of Science and Technology; Seoul National University; National Research Foundation","keywords":"Immunotherapy; Medicine; Immunology; Computer science; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003668098,0.0003124129,0.0003453757,0.0002339763,0.0001419492,0.0004604446,0.000269924,0.0003640162,0.0008549783],"category_scores_gemma":[0.0002079261,0.0001290294,0.00020119,0.0001144871,0.0002679578,0.0001991438,0.0002935466,0.0004499966,0.0003730068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003191491,"about_ca_system_score_gemma":0.0002297493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001676857,"about_ca_topic_score_gemma":0.0004187184,"domain_scores_codex":[0.9996265,0.00007755012,0.00002543934,0.00007425844,0.0001383216,0.00005786684],"domain_scores_gemma":[0.9998914,0.00002760305,0.00002448531,0.00001832239,0.00002221708,0.00001609431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003227117,0.00003025294,0.00008232241,0.00001457311,0.0000018666,0.00002489897,0.00001246481,0.0002439812,0.9974256,0.000157091,0.00002767757,0.001947001],"study_design_scores_gemma":[0.000008600626,0.0002982391,0.0002331212,0.000001802435,0.000004910023,0.00008968735,0.000008754164,0.002088604,0.9961202,0.00002800988,0.001115658,0.00000257913],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9576462,0.0008381027,0.0388073,0.0001111036,0.00002937625,0.0002809242,0.0002642129,0.00027268,0.001750245],"genre_scores_gemma":[0.9791582,0.0003969003,0.01744955,0.00004732813,0.000009376517,0.0001236937,0.0004227732,0.00003782356,0.002354288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008549783,"threshold_uncertainty_score":0.002860129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01639848836613675,"score_gpt":0.2307887911223259,"score_spread":0.2143903027561891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}