{"id":"W4413371619","doi":"10.1039/d5sc04240b","title":"SpectraSage unveils specific proteolytic patterns of 20S on mono-ubiquitylated Tau proteoforms involved in neurodegeneration","year":2025,"lang":"en","type":"article","venue":"Chemical Science","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Ministero dell'Università e della Ricerca; Fondazione Roma; Università di Catania; Ministero dell’Istruzione, dell’Università e della Ricerca; Lazio Innova","keywords":"Neurodegeneration; Proteostasis; Proteasome; Ubiquitin; Regulator; Cell biology; Chemistry; Neuroscience; Biology; Gene; Biochemistry; Medicine; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003926905,0.0001436452,0.0001482076,0.0001074664,0.00005932222,0.00003240025,0.000425221,0.0001150268,0.00002138834],"category_scores_gemma":[0.0001675172,0.0001240832,0.00004871597,0.0005213687,0.0002282798,0.00001118855,0.0001633997,0.0001576914,0.000005657153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005480348,"about_ca_system_score_gemma":0.0001588285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001759377,"about_ca_topic_score_gemma":0.00001067925,"domain_scores_codex":[0.9986152,0.00002873951,0.0002777127,0.0005103338,0.0002277955,0.0003401937],"domain_scores_gemma":[0.999396,0.00001062667,0.000078415,0.0003665411,0.00007000912,0.00007844631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000062208,0.00009976041,0.004500743,0.00003697112,0.000002271014,0.000001457766,0.00003555126,0.00002921405,0.9931821,0.0004458606,0.0000479769,0.00155594],"study_design_scores_gemma":[0.0003768144,0.0001417951,0.006508413,0.00007489896,0.0000017792,8.574651e-7,0.00001894507,0.0002121335,0.9919358,0.0003905039,0.0002078454,0.0001301801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971162,0.00006047671,0.0005179049,0.0001499327,0.00007785935,0.0006843647,0.0000100455,0.00001359033,0.001369611],"genre_scores_gemma":[0.9992175,0.00002983714,0.0003160709,0.0001394182,0.0000545388,0.00007608731,0.00002385087,0.00000748325,0.0001352407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002101258,"threshold_uncertainty_score":0.5059967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01365011377745784,"score_gpt":0.2528180284688261,"score_spread":0.2391679146913682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}