{"id":"W4413375017","doi":"10.1093/biolre/ioaf195","title":"Potential of small extracellular vesicles as Cas9 delivery tool: a promising approach for gene editing livestock gametes and embryos","year":2025,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Zoo","funders":"","keywords":"CRISPR; Genome editing; Biology; Cas9; Electroporation; Extracellular vesicles; Computational biology; Genome; Extracellular vesicle; Somatic cell; Genetics; Biotechnology; Cell biology; Microvesicles; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004861428,0.0001408005,0.0002242318,0.00008626883,0.00007750785,0.000007973996,0.0001245608,0.0002056338,0.000001657151],"category_scores_gemma":[0.0005824807,0.0001509759,0.0001079367,0.00008043813,0.0002992343,0.000006746145,0.000111672,0.0000637611,2.024844e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009265653,"about_ca_system_score_gemma":0.00008944662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002282847,"about_ca_topic_score_gemma":7.921041e-7,"domain_scores_codex":[0.9986551,0.00009838944,0.0003616986,0.0006545993,0.00004936124,0.0001808044],"domain_scores_gemma":[0.9990615,0.00002040604,0.0002495939,0.0004390804,0.0001979266,0.00003147577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002640499,0.0001576842,0.001884847,0.0002537976,0.0001250505,4.945726e-7,0.00003513786,0.0001281849,0.971285,0.0002638478,0.00004437615,0.02555757],"study_design_scores_gemma":[0.0005278239,0.0003664541,0.001930225,0.00002896365,0.0001116446,0.000022225,0.0001554614,0.0003901648,0.9948232,0.0009035361,0.0006104463,0.0001298668],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9236664,0.02584055,0.04960563,0.00006007378,0.0001965029,0.0005431406,0.00001954612,0.00001340839,0.00005472797],"genre_scores_gemma":[0.9337173,0.0002887859,0.0650861,0.000009721726,0.0003805378,0.00004474824,0.0001637241,0.0000154657,0.0002936272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02555176,"threshold_uncertainty_score":0.6156619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01206256201184585,"score_gpt":0.2433167172107535,"score_spread":0.2312541551989076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}