{"id":"W4413376319","doi":"10.1152/ajpregu.00110.2025","title":"The efficacy of foot and neck cooling on autophagy and cellular stress responses in peripheral blood mononuclear cells from older adults exposed to extreme heat","year":2025,"lang":"en","type":"article","venue":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","topic":"Climate Change and Health Impacts","field":"Environmental Science","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; Health Canada","keywords":"Peripheral blood mononuclear cell; Medicine; Heat shock; Relative humidity; Heat stress; Hsp70; Heat shock protein; Apoptosis; Immunology; Andrology; Animal science; Physiology; Internal medicine; Biology; Biochemistry; Meteorology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002870918,0.0002548433,0.0004695535,0.0001084831,0.0002792866,0.0002813696,0.0001239133,0.0002826271,0.00227414],"category_scores_gemma":[0.0003181369,0.0001063226,0.0003530259,0.00008720005,0.0002527782,0.0002192513,0.0002378137,0.0004835339,0.0002095098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001308887,"about_ca_system_score_gemma":0.0002744193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006402971,"about_ca_topic_score_gemma":0.001897025,"domain_scores_codex":[0.9998654,0.00002832689,0.00001268536,0.00003304997,0.00001733252,0.00004332322],"domain_scores_gemma":[0.9998732,0.00002459539,0.00001934158,0.00001136704,0.00003217262,0.0000393959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03469045,0.002466618,0.02171062,0.0007295844,0.0001510636,0.0001435992,0.0008782513,0.0002404831,0.9102467,0.00005405411,0.0004084388,0.02828013],"study_design_scores_gemma":[0.001621009,0.09420802,0.5674109,0.0002330757,0.001023196,0.0003679249,0.002610966,0.00122608,0.3259055,0.0003344346,0.00498729,0.00007162867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986446,0.0006264541,0.0001955299,0.00005238461,0.00002805819,0.0000324268,0.0001627278,0.000002971855,0.0002548062],"genre_scores_gemma":[0.9970951,0.0005459804,0.000580903,0.0001948553,0.00003538059,0.0001692378,0.0003037836,0.000003104447,0.001071495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00227414,"threshold_uncertainty_score":0.007607698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0279715310297056,"score_gpt":0.28804573115071,"score_spread":0.2600742001210044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}