{"id":"W4413377021","doi":"10.1101/2025.08.13.670177","title":"Inhibition of <i>Clostridioides difficile-</i> specific DNA adenine methyltransferase CamA by analogs of <i>S</i> -adenosyl-L-methionine","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Clostridioides; Methyltransferase; Methionine; Chemistry; Pharmacology; Biochemistry; Biology; DNA; Methylation; Microbiology; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000102885,0.0003661219,0.0002283642,0.0002224522,0.000147897,0.00009444578,0.0002412931,0.0001958849,0.002290041],"category_scores_gemma":[0.00008410136,0.00009978939,0.0001575465,0.0001716674,0.0001060172,0.00008419701,0.0001155273,0.000273609,0.0002932322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002674229,"about_ca_system_score_gemma":0.0002229442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00114383,"about_ca_topic_score_gemma":0.002952569,"domain_scores_codex":[0.9999129,0.00001658396,0.000007373304,0.00001483676,0.00002354097,0.00002482335],"domain_scores_gemma":[0.9999593,0.000008135593,0.00001064872,0.000003235862,0.00000820447,0.00001043776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001730504,0.00004417304,0.0001284242,0.0001294474,0.000007163727,0.00003277587,0.000007367658,0.0002776332,0.9949178,0.0000892154,0.0001974924,0.003995607],"study_design_scores_gemma":[0.00004969326,0.001795564,0.00154179,0.00001514338,0.00001765716,0.0001265215,0.0000161079,0.0004968084,0.9910973,0.00002704681,0.004808581,0.000007712795],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.978878,0.004802839,0.00356678,0.0001854921,0.00006888554,0.0001916553,0.001471002,0.000209798,0.01062558],"genre_scores_gemma":[0.9887272,0.002147548,0.004062031,0.00009143907,0.00001008613,0.00007741358,0.001408115,0.00001697925,0.00345916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002290041,"threshold_uncertainty_score":0.007660925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0157503618669232,"score_gpt":0.2501038319014526,"score_spread":0.2343534700345294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}