{"id":"W4413377431","doi":"10.31219/osf.io/k24m6_v1","title":"Cognitive Reserve Disrupts Cognitive Decline from White Matter Hyperintensities","year":2025,"lang":"en","type":"article","venue":"","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; Japan Atomic Energy Agency; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; Natural Sciences and Engineering Research Council of Canada; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association","keywords":"Hyperintensity; Cognitive reserve; Cognitive decline; Cognition; Psychology; White matter; Cognitive impairment; Medicine; Neuroscience; Dementia; Magnetic resonance imaging; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007539971,0.0003743792,0.0002517358,0.0007839429,0.0002505341,0.0006105789,0.0002568061,0.0002258806,0.001072717],"category_scores_gemma":[0.00273148,0.0001422471,0.0003854621,0.0004893892,0.0004758938,0.0005679495,0.0008875228,0.0004542369,0.00009456887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002593355,"about_ca_system_score_gemma":0.0003524964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007477646,"about_ca_topic_score_gemma":0.01831115,"domain_scores_codex":[0.9998447,0.00004242479,0.00001547416,0.00005575225,0.00002387456,0.00001782394],"domain_scores_gemma":[0.9993587,0.0002284308,0.0002357962,0.00008467577,0.00003850237,0.00005399532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001689886,0.0003006683,0.8626741,0.0004895147,0.001612755,0.0007285864,0.002339951,0.01860912,0.03390057,0.002193051,0.001414202,0.07404762],"study_design_scores_gemma":[0.00001483671,0.0001404177,0.9832444,0.00003141912,0.0001487411,0.0003781326,0.0002442355,0.009977696,0.002162681,0.003120025,0.0005194491,0.00001786152],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965208,0.0001502156,0.002441736,0.00005157407,0.000002771081,0.00001244074,0.0004266966,0.00004202983,0.0003518376],"genre_scores_gemma":[0.9972628,0.00008142052,0.001944204,0.00001865887,0.000003863489,0.00001945463,0.0005133255,0.000008206282,0.000148061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007477646,"threshold_uncertainty_score":0.01486826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03673721439777745,"score_gpt":0.3006395102730905,"score_spread":0.2639022958753131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}