{"id":"W4413382315","doi":"10.3389/fimmu.2025.1551017","title":"An exploratory single-cell analysis of peripheral blood mononuclear cells from vedolizumab-treated Crohn’s disease patients identifies response-associated differences among the plasmacytoid dendritic cells and classical monocytes","year":2025,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Universiteit van Amsterdam; Health~Holland; Crohn's and Colitis Foundation; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Vedolizumab; Myeloid; Peripheral blood mononuclear cell; Immunology; Medicine; Toll-like receptor; Immune system; Biology; Crohn's disease; Internal medicine; Innate immune system; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001368876,0.0002631069,0.0005000904,0.000278143,0.0001469451,0.00006707264,0.0004113747,0.0002959708,0.000009977205],"category_scores_gemma":[0.00008548157,0.0002324549,0.000163049,0.0003149643,0.0007134131,0.00002002214,0.0001115148,0.0002032282,4.201888e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005557668,"about_ca_system_score_gemma":0.0000782908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002247878,"about_ca_topic_score_gemma":0.0006180343,"domain_scores_codex":[0.9978578,0.0007310814,0.0004445279,0.0005241429,0.0001157203,0.0003267128],"domain_scores_gemma":[0.9991062,0.0001043578,0.0001622025,0.0004555546,0.00009867232,0.00007303662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002164222,0.000757897,0.4885624,0.000009928213,0.0009775599,0.00001001567,0.0005941597,0.0001303595,0.5063955,0.000001481753,0.0001644472,0.0002320761],"study_design_scores_gemma":[0.001880764,0.0003396896,0.7413582,0.00003015382,0.0008694481,6.856577e-8,0.001091587,0.002186289,0.2518728,0.00007309808,0.00006209284,0.0002358805],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996484,0.002098143,0.0003674216,0.00002508729,0.000585478,0.0002160114,0.0001853205,0.00001881079,0.00001972959],"genre_scores_gemma":[0.998803,0.0004628076,0.000162868,0.00005360761,0.00001399937,0.00001993992,0.0002217658,0.0000232016,0.000238858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2545227,"threshold_uncertainty_score":0.9479236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007132891276522391,"score_gpt":0.1994495592055412,"score_spread":0.1923166679290188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}