{"id":"W4413384171","doi":"10.3389/fendo.2025.1648899","title":"Developmental effects of sulfated thyroid hormones in sea urchin skeletogenesis suggest activation of non-canonical thyroid hormone signaling pathway","year":2025,"lang":"en","type":"article","venue":"Frontiers in Endocrinology","topic":"Thyroid Disorders and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Sea urchin; Thyroid; Hormone; Endocrinology; Sulfation; Internal medicine; Non canonical; Biology; Signal transduction; Chemistry; Cell biology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006897441,0.0001556286,0.0001487621,0.0002467936,0.0001769757,0.0002079146,0.00008584849,0.0002039504,0.001809031],"category_scores_gemma":[0.00007094041,0.0001029885,0.0002539604,0.0001193717,0.0001810303,0.0001571242,0.0002053792,0.0003006874,0.0003042435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002696357,"about_ca_system_score_gemma":0.0001932082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001331029,"about_ca_topic_score_gemma":0.00238722,"domain_scores_codex":[0.9999385,0.000009704901,0.000006107078,0.00001618748,0.00001388067,0.00001569781],"domain_scores_gemma":[0.9998993,0.00001777711,0.00002281555,0.000009545868,0.00002041099,0.00003025275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008368619,0.000005995244,0.001430919,0.00002865949,0.000003018361,0.0000979867,0.00002631912,0.00001523738,0.9971904,0.0000748808,0.00002843738,0.001014427],"study_design_scores_gemma":[0.00001852663,0.0004429208,0.2140874,0.00001577704,0.00003235977,0.0005362696,0.0002577677,0.0008560032,0.7783107,0.0001466261,0.005282043,0.0000136321],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932402,0.002295324,0.001151142,0.0001254276,0.00002210125,0.00001137548,0.0003819846,0.00005293977,0.002719531],"genre_scores_gemma":[0.9947265,0.0008990641,0.000991214,0.00009701381,0.000005619392,0.00002042075,0.0003110671,0.00001043387,0.002938803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001809031,"threshold_uncertainty_score":0.006051838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005677228937886674,"score_gpt":0.2391337401129688,"score_spread":0.2334565111750822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}