{"id":"W4413384729","doi":"10.1371/journal.ppat.1013389","title":"Multivalent mpox protein nanoparticle vaccines confer cross-protection against orthopoxvirus infection","year":2025,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Poxvirus research and outbreaks","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Institute of Microbiology, Chinese Academy of Sciences; National Key Research and Development Program of China; Institute of Genetics and Developmental Biology, Chinese Academy of Sciences; Chinese Academy of Sciences; Bill and Melinda Gates Foundation","keywords":"Vaccinia; Virology; Virus; Orthopoxvirus; Immune system; Antigen; Heterologous; Biology; Monkeypox; Microbiology; Chemistry; Recombinant DNA; Immunology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003019282,0.0002251341,0.0002616091,0.0002188936,0.0004720794,0.00006008005,0.0001544421,0.0003211939,0.00040918],"category_scores_gemma":[0.0004884592,0.0001981092,0.0001384395,0.00033898,0.0001468745,0.0001702532,0.0001436638,0.0004463496,0.001368231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009982252,"about_ca_system_score_gemma":0.0001223776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003171768,"about_ca_topic_score_gemma":0.0002079179,"domain_scores_codex":[0.9982226,0.0003120349,0.0003551145,0.0004396127,0.00008093895,0.0005897026],"domain_scores_gemma":[0.999194,0.00004867416,0.00008917359,0.0003808421,0.0002357034,0.00005161844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003128078,0.0003406857,0.03204649,0.00006297213,0.0001759607,0.0000106842,0.00008132697,0.00001261781,0.9501784,0.0002436307,0.0001945231,0.01633992],"study_design_scores_gemma":[0.001567727,0.0001386793,0.06691011,0.00007672696,0.00003065514,0.000005697753,0.00002614898,0.00008355494,0.9150709,0.0001332764,0.01576339,0.0001931529],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994479,0.0006988688,0.0003064591,0.0002188611,0.0004417343,0.001042026,0.00007389753,0.0002608625,0.002478288],"genre_scores_gemma":[0.9887889,0.00008536247,0.00003875258,0.0001480385,0.00004887781,0.0003859082,0.00005244777,0.00002075151,0.01043095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03510749,"threshold_uncertainty_score":0.9994093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02702239943290629,"score_gpt":0.2862058775148481,"score_spread":0.2591834780819418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}