{"id":"W4413384729","doi":"10.1371/journal.ppat.1013389","title":"Multivalent mpox protein nanoparticle vaccines confer cross-protection against orthopoxvirus infection","year":2025,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Poxvirus research and outbreaks","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Institute of Microbiology, Chinese Academy of Sciences; National Key Research and Development Program of China; Institute of Genetics and Developmental Biology, Chinese Academy of Sciences; Chinese Academy of Sciences; Bill and Melinda Gates Foundation","keywords":"Vaccinia; Virology; Virus; Orthopoxvirus; Immune system; Antigen; Heterologous; Biology; Monkeypox; Microbiology; Chemistry; Recombinant DNA; Immunology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001534013,0.0003259289,0.0001828789,0.000161601,0.00007376214,0.0002106572,0.0001196393,0.0003338038,0.0004899657],"category_scores_gemma":[0.0001081136,0.0001120018,0.0001790196,0.00005104969,0.0001278066,0.0002218062,0.0002770126,0.000330728,0.0001327188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001626562,"about_ca_system_score_gemma":0.0001042495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002470576,"about_ca_topic_score_gemma":0.0003695773,"domain_scores_codex":[0.9999026,0.0000166625,0.000007351694,0.00002560156,0.00002174947,0.00002603227],"domain_scores_gemma":[0.999956,0.000008236256,0.00001177242,0.000004300808,0.000008754299,0.00001097507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005111562,0.00002887377,0.00009630714,0.00003040765,0.000005175829,0.000016773,0.000008656772,0.0001060867,0.997431,0.00005095797,0.00002238413,0.002152254],"study_design_scores_gemma":[0.00001754288,0.0009997012,0.002020175,0.000009740249,0.00003491003,0.0002152344,0.00001669832,0.001806212,0.9927744,0.00006271663,0.002039027,0.000003703768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935338,0.001150818,0.004070702,0.00005948365,0.00002886185,0.0000309196,0.00003900095,0.0000607715,0.001025524],"genre_scores_gemma":[0.9951051,0.0004699445,0.003143032,0.00005143332,0.000009900014,0.00001622408,0.00007406886,0.000008543344,0.001121775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004899657,"threshold_uncertainty_score":0.001639128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02702239943290629,"score_gpt":0.2862058775148481,"score_spread":0.2591834780819418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}