{"id":"W4413385114","doi":"10.1101/2025.08.14.669875","title":"Mesenchymal Stromal Cells Immunosuppress Osteoarthritis Synovial Fluid Modulated Monocytes via IL-6 and CCL2","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Bone and Joint Diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Arthritis Society","keywords":"Mesenchymal stem cell; Synovial fluid; Osteoarthritis; Stromal cell; Chemistry; Medicine; Cancer research; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002887312,0.0008834309,0.001317368,0.0004607336,0.0002255581,0.0002315246,0.0003481841,0.0008705276,0.0001357686],"category_scores_gemma":[0.0001633043,0.0009534432,0.0003425095,0.0004283966,0.0002883317,0.0001975972,0.0008918028,0.001020878,0.00004964862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001952261,"about_ca_system_score_gemma":0.0009432101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002087151,"about_ca_topic_score_gemma":0.000002993842,"domain_scores_codex":[0.9962146,0.0001641581,0.0008583005,0.001405263,0.0005420207,0.0008156392],"domain_scores_gemma":[0.9968454,0.0001048014,0.0003162591,0.00157553,0.0005705685,0.0005874008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004617461,0.0003772464,0.003849408,0.001299766,0.0005130819,0.0005557539,0.00001461656,0.00002917614,0.9918702,0.00008000393,0.0009045654,0.00004439082],"study_design_scores_gemma":[0.004271725,0.0005208458,0.1178537,0.002489723,0.001282601,4.382713e-7,0.000009370711,0.001757954,0.8667884,0.000005925791,0.003626046,0.001393241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861742,0.008133627,0.0002812122,0.0003152019,0.001466098,0.001437252,0.001560953,0.0005847521,0.00004669202],"genre_scores_gemma":[0.9955259,0.000874533,0.002333296,0.0002844231,0.0005940467,0.0002014176,0.000004695341,0.0001244878,0.00005720393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1250818,"threshold_uncertainty_score":0.9992916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00866079633736424,"score_gpt":0.2155975466581353,"score_spread":0.206936750320771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}