{"id":"W4413385171","doi":"10.1016/j.cell.2025.07.041","title":"Adenosine kinase and ADAL coordinate detoxification of modified adenosines to safeguard metabolism","year":2025,"lang":"en","type":"article","venue":"Cell","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fusion Oriented REsearch for disruptive Science and Technology; Exploratory Research for Advanced Technology; Japan Society for the Promotion of Science; Japan Science and Technology Agency; Daiichi Sankyo Foundation of Life Science; Astellas Foundation for Research on Metabolic Disorders; Inamori Foundation; Gout and Uric Acid Foundation; Ministry of Education - Singapore; National Research Foundation; Japan Science and Technology Corporation; National Research Foundation Singapore; Sumitomo Foundation; Mitsubishi Foundation; Takeda Science Foundation; Japan Society for the Promotion of Science London; Japan Agency for Medical Research and Development; University of Waterloo; Naito Foundation","keywords":"Biology; Adenosine; Detoxification (alternative medicine); Metabolism; Biochemistry; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008392962,0.0001177421,0.0001535681,0.000077253,0.00004584116,0.00001240392,0.0001231843,0.00009519098,0.00001137094],"category_scores_gemma":[0.00004111937,0.0001136238,0.00004160282,0.0001553522,0.00004079828,0.000003134197,0.00009721948,0.00004631163,0.000003150935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000415524,"about_ca_system_score_gemma":0.00003903346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002943575,"about_ca_topic_score_gemma":0.000001894799,"domain_scores_codex":[0.9993232,0.00002907073,0.0001912679,0.0002537848,0.0000648425,0.0001378595],"domain_scores_gemma":[0.9995404,0.00001260903,0.00005723172,0.0002315174,0.0001004402,0.00005775457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001169226,0.00005035207,0.0002593363,0.00005708196,0.00002340547,0.000001394823,0.00004391569,0.0002362305,0.9843819,0.0004889864,0.01333176,0.001008776],"study_design_scores_gemma":[0.0005292629,0.00006550823,0.003264932,0.00002049155,0.00005047299,0.000001770652,0.00005008209,0.00008259642,0.9650269,0.0001333676,0.03064886,0.0001257097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9754635,0.01228539,0.00851631,0.0005207912,0.0001277581,0.0001781664,0.00001543199,0.00001024019,0.002882432],"genre_scores_gemma":[0.9948615,0.0001593161,0.0007625239,0.0002405034,0.0001031658,0.00001421161,0.00004310781,0.00001091109,0.003804755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01939802,"threshold_uncertainty_score":0.4633443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007002765571877323,"score_gpt":0.2388328468800268,"score_spread":0.2318300813081494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}