{"id":"W4413385171","doi":"10.1016/j.cell.2025.07.041","title":"Adenosine kinase and ADAL coordinate detoxification of modified adenosines to safeguard metabolism","year":2025,"lang":"en","type":"article","venue":"Cell","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fusion Oriented REsearch for disruptive Science and Technology; Exploratory Research for Advanced Technology; Japan Society for the Promotion of Science; Japan Science and Technology Agency; Daiichi Sankyo Foundation of Life Science; Astellas Foundation for Research on Metabolic Disorders; Inamori Foundation; Gout and Uric Acid Foundation; Ministry of Education - Singapore; National Research Foundation; Japan Science and Technology Corporation; National Research Foundation Singapore; Sumitomo Foundation; Mitsubishi Foundation; Takeda Science Foundation; Japan Society for the Promotion of Science London; Japan Agency for Medical Research and Development; University of Waterloo; Naito Foundation","keywords":"Biology; Adenosine; Detoxification (alternative medicine); Metabolism; Biochemistry; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001309954,0.0002930874,0.0002567701,0.0001510105,0.0001517628,0.0004829708,0.0001922737,0.0002992472,0.0006740976],"category_scores_gemma":[0.00008311759,0.0001183869,0.0001601526,0.00006831099,0.0002566249,0.0002912379,0.0002735711,0.0003614619,0.0003005774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002925425,"about_ca_system_score_gemma":0.0001987716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001548369,"about_ca_topic_score_gemma":0.0003297013,"domain_scores_codex":[0.9998939,0.0000172378,0.00001012815,0.0000286943,0.00002315928,0.00002692528],"domain_scores_gemma":[0.999907,0.000006345882,0.00003680175,0.00001068573,0.00001200137,0.00002706878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001399737,0.00001345264,0.0003343008,0.0000379427,0.000004240921,0.0000886629,0.00001365496,0.0001159233,0.9960582,0.0006922883,0.00005504633,0.002446309],"study_design_scores_gemma":[0.00001995671,0.0002714932,0.00416272,0.000008442356,0.00001387587,0.0004347051,0.00004078373,0.001634034,0.987353,0.0004741454,0.005577783,0.000009056367],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9712833,0.009144187,0.01382883,0.0004087239,0.0001169404,0.00004609436,0.0002641652,0.0002792744,0.004628395],"genre_scores_gemma":[0.9914175,0.001459875,0.004757392,0.0000855699,0.00002831706,0.00002266949,0.0001302171,0.00001245454,0.00208602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006740976,"threshold_uncertainty_score":0.002255082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007002765571877323,"score_gpt":0.2388328468800268,"score_spread":0.2318300813081494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}