{"id":"W4413386609","doi":"10.1101/2025.08.19.25332842","title":"HNK-1 Antibody-Based ELISA for Soluble PTPRZ: A Practical Cerebrospinal Fluid Biomarker for Glioma","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Glycomics Network; Institute of Medical Science, University of Tokyo; Ministry of Education, Culture, Sports, Science and Technology; University of Tokyo; Japan Agency for Medical Research and Development; Mizutani Foundation for Glycoscience","keywords":"Cerebrospinal fluid; Biomarker; Glioma; Antibody; Medicine; Chemistry; Cancer research; Pathology; Immunology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008120791,0.0006653931,0.0003817613,0.0009805168,0.0001777448,0.0007059658,0.000279101,0.0006158325,0.002129429],"category_scores_gemma":[0.0009652826,0.0002456148,0.0002276108,0.0003941701,0.0003228425,0.0003028088,0.0002867887,0.0006554733,0.001274845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002790462,"about_ca_system_score_gemma":0.0003158142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005214998,"about_ca_topic_score_gemma":0.001019331,"domain_scores_codex":[0.9993493,0.0001658969,0.00005278982,0.0001585321,0.0002109503,0.00006250964],"domain_scores_gemma":[0.9997217,0.00007446011,0.00007300126,0.0000287933,0.00007119446,0.00003086414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000312873,0.00007388757,0.01478688,0.0002860387,0.00007125309,0.0001179365,0.00004044167,0.0003829431,0.9647535,0.0002427111,0.001079969,0.01785154],"study_design_scores_gemma":[0.00006620932,0.0006479683,0.05327827,0.00007343732,0.0001305684,0.002042385,0.00008824874,0.01176536,0.9227388,0.0007688854,0.008370996,0.00002889449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8866517,0.01299871,0.08644972,0.0009760961,0.00033619,0.0004006704,0.004734344,0.001657481,0.005795023],"genre_scores_gemma":[0.9179451,0.00274534,0.07045957,0.0003449181,0.0001372718,0.0002522542,0.003477381,0.00007968796,0.0045585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002129429,"threshold_uncertainty_score":0.007123649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0614934745065157,"score_gpt":0.3905360495236621,"score_spread":0.3290425750171463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}