{"id":"W4413396136","doi":"10.1158/0008-5472.can-25-3656","title":"Transient Nutrient Sensing Shapes T-cell Exhaustion","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; BC Cancer Agency","funders":"","keywords":"Context (archaeology); T-cell receptor; Cell biology; T cell; Cell fate determination; Extracellular; Intracellular; Biology; Cytokine; Methionine; Transcription factor; Immune system; Immunology; Biochemistry; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000120878,0.0001223324,0.000257833,0.0001378379,0.0002241084,0.0007625205,0.0001887661,0.0004510698,0.001881785],"category_scores_gemma":[0.0002839299,0.000147066,0.0001667454,0.0001044997,0.0003411503,0.0004967275,0.0005028807,0.0007235897,0.0006339686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004613021,"about_ca_system_score_gemma":0.0002556143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003252624,"about_ca_topic_score_gemma":0.0006167234,"domain_scores_codex":[0.9998324,0.00001930276,0.000009080315,0.00004504323,0.000038596,0.00005550784],"domain_scores_gemma":[0.9998742,0.00002434189,0.00002294091,0.00001211383,0.0000181899,0.00004817382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005230741,0.00002284266,0.0009370124,0.00004738553,0.000004626831,0.00009079987,0.0000549252,0.0002766918,0.9918241,0.0008628262,0.0003591068,0.004996687],"study_design_scores_gemma":[0.00007521548,0.0006877344,0.02853077,0.0000352337,0.00003580002,0.0004971163,0.0005398835,0.005785506,0.9415945,0.002814127,0.0193584,0.00004574239],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888526,0.002481196,0.003021953,0.0005035927,0.0001203681,0.00001037372,0.0002596499,0.0001847643,0.00456553],"genre_scores_gemma":[0.9969634,0.0005473392,0.0007343719,0.0001598443,0.00001983147,0.00001171478,0.0001091992,0.00002980778,0.001424422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001881785,"threshold_uncertainty_score":0.006295204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04318422753025512,"score_gpt":0.3586757048300258,"score_spread":0.3154914772997706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}