{"id":"W4413396177","doi":"10.71000/xghqe876","title":"ROLE OF EPIGENETIC MODIFICATIONS IN TUMOR SUPPRESSOR GENE SILENCING AMONG PATIENTS WITH SPORADIC COLORECTAL CANCER: NARRATIVE REVIEW","year":2025,"lang":"en","type":"article","venue":"Insights-Journal of Health and Rehabilitation","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alpha Technologies (Canada)","funders":"","keywords":"Epigenetics; Gene silencing; Colorectal cancer; Suppressor; Cancer research; Tumor suppressor gene; Gene; Medicine; Cancer; Biology; Genetics; Carcinogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007446284,0.000445581,0.0007258128,0.001555638,0.0001523096,0.0006691783,0.0004048345,0.0007025265,0.001096577],"category_scores_gemma":[0.002745048,0.0001478283,0.0004999592,0.001353745,0.0002718667,0.0006483553,0.0003842027,0.0005129312,0.0002089295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004450981,"about_ca_system_score_gemma":0.001125712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001144151,"about_ca_topic_score_gemma":0.001607304,"domain_scores_codex":[0.9997029,0.00008477774,0.00008431871,0.00006287632,0.00005016515,0.00001493465],"domain_scores_gemma":[0.9986975,0.0009034873,0.0002277602,0.00001468066,0.0001289221,0.00002769904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002165884,0.00003267505,0.004178103,0.1224344,0.0007734048,0.001105994,0.0005823766,0.0004869495,0.0009888354,0.003710802,0.03190788,0.833582],"study_design_scores_gemma":[0.00004172303,0.0003729719,0.02071854,0.104084,0.003617844,0.01965428,0.001063763,0.0003593238,0.001217005,0.003320183,0.8454595,0.00009077308],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004976798,0.9984097,0.00009615153,0.0004611162,0.0001297145,0.000005656369,0.00005227947,0.000002528083,0.0003451546],"genre_scores_gemma":[0.004485766,0.994568,0.0001547204,0.0003411585,0.0002629856,0.00001053323,0.00006367789,0.000001106797,0.0001120541],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001555638,"threshold_uncertainty_score":0.003938019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0049952177433707,"score_gpt":0.2710617279368981,"score_spread":0.2660665101935275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}