{"id":"W4413406089","doi":"10.1016/j.jacig.2025.100558","title":"Protocol design for the ACTIVATE clinical trial: Exposure to vaginal microbiome in cesarean-delivered infants at high risk for allergies","year":2025,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology Global","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Works and Government Services Canada","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Food Allergy Research and Education","keywords":"Microbiome; Allergy; Medicine; Protocol (science); Obstetrics; Clinical trial; Bioinformatics; Internal medicine; Immunology; Biology; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02930724,0.006457411,0.007381807,0.001827243,0.003457101,0.00489013,0.00261013,0.008744793,0.10521],"category_scores_gemma":[0.04119331,0.003023224,0.004695171,0.002119041,0.003492691,0.003604793,0.002015233,0.008639002,0.02039844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003162883,"about_ca_system_score_gemma":0.0131383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001499193,"about_ca_topic_score_gemma":0.003446469,"domain_scores_codex":[0.9769453,0.01441133,0.00233441,0.002659156,0.00191732,0.00173246],"domain_scores_gemma":[0.9852744,0.004553115,0.002881503,0.002576077,0.002478613,0.002236229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8738022,0.006557029,0.00120655,0.01588541,0.002300641,0.0002969705,0.0003914743,0.001685565,0.002113201,0.009048748,0.0531733,0.03353899],"study_design_scores_gemma":[0.9097195,0.01578319,0.002063819,0.003196287,0.001016055,0.00009182448,0.00008790233,0.002727412,0.001002766,0.00676473,0.05740551,0.0001409253],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.001888534,0.0005277559,0.002661842,0.000552059,0.001483595,0.9866962,0.003331336,0.0002766418,0.002582073],"genre_scores_gemma":[0.002635025,0.0001329884,0.002080146,0.0004913672,0.0001374164,0.9934236,0.0002611909,0.00001429208,0.000823991],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.10521,"threshold_uncertainty_score":0.3519624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03994805786892953,"score_gpt":0.3995489897879029,"score_spread":0.3596009319189734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}