{"id":"W4413408517","doi":"10.1016/j.euo.2025.06.010","title":"A Deep Prostate-specific Antigen Response to Darolutamide plus Androgen Deprivation Therapy Is Associated with Better Clinical Outcomes in the Phase 3 ARANOTE Trial in Patients with Metastatic Hormone-sensitive Prostate Cancer","year":2025,"lang":"en","type":"article","venue":"European Urology Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Pharmaceuticals Bayer","keywords":"Medicine; Androgen deprivation therapy; Prostate cancer; Prostate-specific antigen; Oncology; Internal medicine; Clinical trial; Hormone therapy; Prostate; Androgen; Hormone; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002552829,0.0003055827,0.0008730791,0.0004725496,0.0001104673,0.00002531533,0.0002059508,0.0001131242,0.00001741835],"category_scores_gemma":[0.0003564927,0.0001725092,0.00008155828,0.0008173313,0.0003918244,0.00008010474,0.00007343573,0.0006697855,0.00002080967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000456122,"about_ca_system_score_gemma":0.0006750387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005109742,"about_ca_topic_score_gemma":0.0002674068,"domain_scores_codex":[0.9935442,0.004132901,0.0007102448,0.0006709092,0.0003288498,0.0006129125],"domain_scores_gemma":[0.9978722,0.00115851,0.0002305024,0.0003970343,0.000235697,0.0001060406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5711449,0.002031157,0.4061375,0.000003553735,0.0005462961,0.001479774,0.005753628,0.00004723125,0.0001287888,0.000001890564,0.0003539588,0.01237126],"study_design_scores_gemma":[0.2283626,0.02258617,0.7437983,0.00002753322,0.00009413503,0.000004815337,0.0001588007,0.00005793008,0.00004209422,0.00001406014,0.004712674,0.0001408257],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796168,0.0003323959,0.00006185704,0.01429391,0.0001231985,0.005259271,0.00006207881,0.00003330542,0.000217147],"genre_scores_gemma":[0.9876611,0.000336846,0.0001490308,0.01106438,0.00003712498,0.0003294442,0.0001437014,0.00004543861,0.0002329076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3427823,"threshold_uncertainty_score":0.7034723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04418878044786725,"score_gpt":0.3790631417130382,"score_spread":0.334874361265171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}