{"id":"W4413410108","doi":"10.1007/s00204-025-04158-1","title":"Sirtuins as mediators and targets of arsenic toxicity: unraveling signaling pathway crosstalk","year":2025,"lang":"en","type":"review","venue":"Archives of Toxicology","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Sirtuin; SIRT2; SIRT3; Biology; Autophagy; Neurodegeneration; Cell biology; Sirtuin 1; Oxidative stress; Arsenic toxicity; DNA damage; Histone deacetylase; Histone; Chemistry; Arsenic; NAD+ kinase; Medicine; Biochemistry; Apoptosis; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007260345,0.0008167634,0.001345016,0.001617018,0.0002546158,0.001312807,0.0008558464,0.00107527,0.002952466],"category_scores_gemma":[0.0006281425,0.0002566487,0.0004932557,0.001826923,0.0005493045,0.001364458,0.0007480194,0.002114449,0.001426421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005633181,"about_ca_system_score_gemma":0.00114172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007906549,"about_ca_topic_score_gemma":0.002242009,"domain_scores_codex":[0.9998441,0.00003025644,0.00002046321,0.00002800143,0.00005898781,0.00001809724],"domain_scores_gemma":[0.9997286,0.0001129109,0.0000384481,0.000009706954,0.00008172387,0.00002847346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002039182,0.00009796416,0.0003510639,0.01711941,0.0002219281,0.0002623047,0.00009601604,0.000471521,0.0061495,0.008644024,0.02455937,0.9418229],"study_design_scores_gemma":[0.00003414728,0.0001526898,0.0009479334,0.002231509,0.0002589995,0.0007046643,0.0001142278,0.0001860889,0.001523975,0.004084625,0.9897332,0.00002813217],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001250532,0.9987291,0.000134295,0.0002840591,0.0001529598,0.000002415998,0.00001530523,0.000006860298,0.0005499424],"genre_scores_gemma":[0.0009198971,0.998161,0.0001810106,0.0001593063,0.0001674426,0.000003513244,0.00002686314,9.208458e-7,0.0003799832],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002952466,"threshold_uncertainty_score":0.009876966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02029596137237743,"score_gpt":0.3298044737347686,"score_spread":0.3095085123623911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}