{"id":"W4413411072","doi":"10.1002/bit.70043","title":"Endogenous Retrovirus‐Like Particle‐Deficient CHO Cells Can be Generated by CRISPR or shRNA and Enriched Based on Cell‐Surface Expression of Retroviral Envelope Protein","year":2025,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"National Research Council Canada","keywords":"Chinese hamster ovary cell; Retrovirus; CRISPR; Biology; Murine leukemia virus; Endogenous retrovirus; Cell culture; Viral envelope; Virology; Cell biology; Virus; Recombinant DNA; Small hairpin RNA; Viral vector; Capsid; Molecular biology; Gene; Genetics; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002383353,0.0004437014,0.0003305344,0.0003318656,0.0002073344,0.0005363181,0.0003361223,0.0003860685,0.001486511],"category_scores_gemma":[0.0001595861,0.0001826206,0.0003189818,0.0002191199,0.0003236595,0.0002498711,0.0004226104,0.0006113505,0.0009890816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003033393,"about_ca_system_score_gemma":0.0002593946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005225712,"about_ca_topic_score_gemma":0.001107104,"domain_scores_codex":[0.9997813,0.00002448485,0.00003439554,0.00004664176,0.00008073998,0.00003249608],"domain_scores_gemma":[0.9998506,0.00002930008,0.00004423572,0.00003877161,0.00001987391,0.00001718833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001419668,0.000006005879,0.00008791318,0.00002236487,0.000003812843,0.00002973689,0.00001303352,0.00001867141,0.9988984,0.0001609918,0.00002784458,0.0007170019],"study_design_scores_gemma":[0.000005433053,0.00005403277,0.0009159647,0.000004356713,0.00001378217,0.0001528347,0.00001413747,0.000400784,0.9920641,0.00005207189,0.006317595,0.000004959553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9198313,0.001740875,0.06339251,0.0002153255,0.0002115564,0.000297584,0.003565411,0.0009376785,0.00980772],"genre_scores_gemma":[0.9375948,0.001417758,0.04249422,0.0001672953,0.00001908303,0.0002712836,0.004704378,0.0003006326,0.01303063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001486511,"threshold_uncertainty_score":0.004972875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008516880894238757,"score_gpt":0.2153143853068364,"score_spread":0.2067975044125976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}