{"id":"W4413427887","doi":"10.3390/biomedicines13092052","title":"In Vivo Characterization of ONL1204, a Small Peptide Inhibitor of the Fas Receptor, as a Potential Neuroprotective Therapy for Geographic Atrophy and Dry Age-Related Macular Degeneration","year":2025,"lang":"en","type":"article","venue":"Biomedicines","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Altasciences (Canada)","funders":"National Institutes of Health; National Eye Institute; Johns Hopkins University; Western Michigan University; Research to Prevent Blindness","keywords":"Neuroprotection; Geographic atrophy; In vivo; Atrophy; Macular degeneration; Medicine; Peptide; Pharmacology; Pathology; Biology; Ophthalmology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000301141,0.0003625173,0.0002170215,0.0002347228,0.00009526491,0.0002948492,0.0002173286,0.0002905836,0.0007786694],"category_scores_gemma":[0.0002232135,0.0001102045,0.0002744672,0.0001327392,0.0001889959,0.0002348018,0.00006604289,0.0004256145,0.0002697167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003286453,"about_ca_system_score_gemma":0.0003117034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009475229,"about_ca_topic_score_gemma":0.0007969471,"domain_scores_codex":[0.9998909,0.00002312577,0.00000516173,0.00002010221,0.00003052113,0.00003025518],"domain_scores_gemma":[0.9998112,0.00003131485,0.00007121503,0.00001927035,0.00002946841,0.00003743775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006898575,0.0002636448,0.0003119415,0.00003302616,0.0000108284,0.00004632058,0.00001951048,0.0001656145,0.9947173,0.00003584538,0.00005975806,0.00364633],"study_design_scores_gemma":[0.0002277525,0.02285727,0.01230886,0.00001230905,0.0001098046,0.0006964291,0.00005654954,0.003356948,0.9568348,0.00006763254,0.003458809,0.00001271406],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961705,0.001115188,0.001612102,0.00003918284,0.00001272469,0.00006421156,0.0001970924,0.00002178729,0.0007672595],"genre_scores_gemma":[0.9943816,0.00112284,0.001812144,0.00005559291,0.00001474541,0.00007527174,0.0006886487,0.00002092335,0.001828279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009475229,"threshold_uncertainty_score":0.002604902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006454301403490021,"score_gpt":0.2402559883802836,"score_spread":0.2338016869767935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}