{"id":"W4413431666","doi":"10.1136/thorax-2025-222990","title":"Serum IgA isotypes are associated with percent emphysema, wall thickness and lung function decline","year":2025,"lang":"en","type":"article","venue":"Thorax","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"National Center for Advancing Translational Sciences; National Institute of Environmental Health Sciences; National Human Genome Research Institute; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Medicine; Lung function; Lung; Pulmonary emphysema; Immunoglobulin A; Cardiology; Immunology; Internal medicine; Immunoglobulin G; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002744207,0.0001825015,0.0002660549,0.00009028159,0.0003820956,0.00002705723,0.0001416531,0.0002282393,0.0001610726],"category_scores_gemma":[0.0000658576,0.0001449275,0.00004675887,0.0002444283,0.0001879215,0.00009116888,0.00009764427,0.0002962036,0.0000554017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003526176,"about_ca_system_score_gemma":0.00005767681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001041934,"about_ca_topic_score_gemma":0.00006449012,"domain_scores_codex":[0.9990254,0.0001570338,0.000198516,0.0002740031,0.0000359877,0.0003090847],"domain_scores_gemma":[0.9994873,0.00008976916,0.0001035197,0.0002202227,0.00009401698,0.000005132704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006479949,0.003340072,0.3409243,0.000812655,0.005285717,0.00004104408,0.009103271,0.0004632141,0.3974994,0.01747675,0.01057192,0.2080017],"study_design_scores_gemma":[0.002673586,0.0002271087,0.9653495,0.0004661091,0.0003490562,0.00001371615,0.002724498,0.0001235024,0.004321706,0.0007899115,0.02254805,0.0004132758],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9661185,0.02898296,0.0005031527,0.001254756,0.000537553,0.0002238793,0.00001634506,0.0001411782,0.00222167],"genre_scores_gemma":[0.9915057,0.0001445724,0.000005417806,0.0008463613,0.000002237165,0.00001521565,0.0001081673,0.00001242075,0.007359842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6244252,"threshold_uncertainty_score":0.5909973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005924611651853436,"score_gpt":0.2269738733814267,"score_spread":0.2210492617295733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}