{"id":"W4413440199","doi":"10.56048/mqr20225.9.3.2025.e946","title":"Mutaciones en los genes PSEN1 y PSEN2 como marcadores moleculares en la Enfermedad de Alzheimer. Revisión Sistemática.","year":2025,"lang":"es","type":"article","venue":"MQRInvestigar","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"PSEN1; Biology; Alzheimer's disease; Medicine; Molecular biology; Presenilin; Disease; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02883204,0.001732821,0.003152991,0.02074884,0.001087349,0.005563205,0.003184573,0.002614221,0.005295821],"category_scores_gemma":[0.06227296,0.001043414,0.004231377,0.01096718,0.004156963,0.005976873,0.002683324,0.002936074,0.002082364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003652752,"about_ca_system_score_gemma":0.01402521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007219382,"about_ca_topic_score_gemma":0.00690666,"domain_scores_codex":[0.981195,0.005130088,0.006833353,0.001695402,0.00476833,0.0003778654],"domain_scores_gemma":[0.9149226,0.04938467,0.01364397,0.002881461,0.01838257,0.0007847056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.000692378,0.00009384778,0.01034627,0.1370009,0.00193437,0.0005289508,0.001594751,0.0005001119,0.001722053,0.007400474,0.05201853,0.7861674],"study_design_scores_gemma":[0.0002339394,0.0005997348,0.02988204,0.2168304,0.008116098,0.003996381,0.001579154,0.0008199623,0.002466759,0.01647158,0.7187199,0.0002841461],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001579317,0.9801032,0.002440534,0.008243552,0.003840187,0.0001928338,0.00156309,0.0001578535,0.001879522],"genre_scores_gemma":[0.02168975,0.9503862,0.01160802,0.00510546,0.004397177,0.0009023088,0.003709837,0.00008511214,0.002116161],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.02883204,"threshold_uncertainty_score":0.1524802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01843126552047069,"score_gpt":0.333848975644377,"score_spread":0.3154177101239063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}