{"id":"W4413453180","doi":"10.1093/braincomms/fcaf306","title":"Persistent progression independent of relapse activity in multiple sclerosis","year":2025,"lang":"en","type":"article","venue":"Brain Communications","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cegep de Saint Jerome; Centre Intégré de Santé et Services Sociaux de Chaudière-Appalache; Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Health and Medical Research Council; EMD Serono; International Progressive MS Alliance; Genentech; Trish Multiple Sclerosis Research Foundation; Sanofi; Multiple Sclerosis International Federation; Biogen; Všeobecná Fakultní Nemocnice v Praze; GlaxoSmithKline; Università di Catania; Eisai; National Research Foundation; Multiple Sclerosis Australia; Univerzita Karlova v Praze; Celgene; Alnylam Pharmaceuticals; Alexion Pharmaceuticals; Medical Research Council; Teva Pharmaceutical Industries; MedDay Pharmaceuticals; Bayer HealthCare; Novartis Pharma; European Commission; World Health Organization; Sanofi Genzyme; Universität Basel; Bristol-Myers Squibb","keywords":"Expanded Disability Status Scale; Proportional hazards model; Medicine; Multiple sclerosis; Persistence (discontinuity); Cohort; Internal medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001305148,0.0001705269,0.0003391891,0.0006010855,0.0003178465,0.0006728342,0.0003194176,0.0002867685,0.001891255],"category_scores_gemma":[0.003437233,0.0001697194,0.0007194527,0.0007153541,0.0002247894,0.0005103892,0.0006156165,0.000715944,0.0001882255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001959628,"about_ca_system_score_gemma":0.0003365186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001013558,"about_ca_topic_score_gemma":0.000881025,"domain_scores_codex":[0.9993076,0.0001969376,0.00008267572,0.0001608032,0.0001300685,0.0001219076],"domain_scores_gemma":[0.9968521,0.0005821818,0.001795384,0.0003069264,0.0001519938,0.0003114558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001647027,0.0001037933,0.9900969,0.00003835401,0.0001980521,0.0002078191,0.00004365802,0.0002066162,0.0004284605,0.000115995,0.0001443401,0.006768855],"study_design_scores_gemma":[0.00005310674,0.0006355757,0.9958163,0.0000113576,0.0001062435,0.0008301416,0.00005995168,0.001807802,0.000157499,0.0003076622,0.0002084135,0.00000598261],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990005,0.0002847913,0.0001983909,0.00003406449,0.000005049357,0.000008238373,0.0002027312,0.000006547878,0.0002596838],"genre_scores_gemma":[0.9997383,0.0000306812,0.00004273916,0.000005671674,0.000005761512,0.000004856457,0.0001123557,0.000001222966,0.00005851699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001891255,"threshold_uncertainty_score":0.006902337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1605495685952651,"score_gpt":0.3871334998699295,"score_spread":0.2265839312746643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}