{"id":"W4413453180","doi":"10.1093/braincomms/fcaf306","title":"Persistent progression independent of relapse activity in multiple sclerosis","year":2025,"lang":"en","type":"article","venue":"Brain Communications","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cegep de Saint Jerome; Centre Intégré de Santé et Services Sociaux de Chaudière-Appalache; Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Health and Medical Research Council; EMD Serono; International Progressive MS Alliance; Genentech; Trish Multiple Sclerosis Research Foundation; Sanofi; Multiple Sclerosis International Federation; Biogen; Všeobecná Fakultní Nemocnice v Praze; GlaxoSmithKline; Università di Catania; Eisai; National Research Foundation; Multiple Sclerosis Australia; Univerzita Karlova v Praze; Celgene; Alnylam Pharmaceuticals; Alexion Pharmaceuticals; Medical Research Council; Teva Pharmaceutical Industries; MedDay Pharmaceuticals; Bayer HealthCare; Novartis Pharma; European Commission; World Health Organization; Sanofi Genzyme; Universität Basel; Bristol-Myers Squibb","keywords":"Expanded Disability Status Scale; Proportional hazards model; Medicine; Multiple sclerosis; Persistence (discontinuity); Cohort; Internal medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006261576,0.0001040641,0.0002814542,0.0003187177,0.0001958563,0.00001115476,0.0004619246,0.00008296916,0.00001879988],"category_scores_gemma":[0.002419035,0.00009366903,0.0001401358,0.0006232455,0.0003427657,0.00006992149,0.0009051978,0.00040681,0.000006606303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002311205,"about_ca_system_score_gemma":0.0001659889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003532921,"about_ca_topic_score_gemma":0.0010347,"domain_scores_codex":[0.9987189,0.0002867418,0.0002987551,0.0001957889,0.0002942681,0.0002055971],"domain_scores_gemma":[0.9968821,0.001140658,0.00008979219,0.001637198,0.000184012,0.0000661786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005383561,0.00433891,0.531716,0.0004224832,0.0003443397,0.000001906379,0.002294876,0.00004480433,0.2721048,0.001039587,0.006026164,0.1811277],"study_design_scores_gemma":[0.002454833,0.0001065691,0.9804392,0.001164318,0.00003057193,8.494252e-7,0.0007778591,0.005377262,0.005657739,0.00003349328,0.003875549,0.00008178547],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9389218,0.00217031,0.0001177181,0.04534851,0.00004766163,0.001438838,0.00002444946,0.00006229862,0.01186841],"genre_scores_gemma":[0.9942611,0.001507596,0.003261154,0.0001427087,0.000006180026,0.0002683619,0.0000188822,0.000009146789,0.0005248316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4487231,"threshold_uncertainty_score":0.3819712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1605495685952651,"score_gpt":0.3871334998699295,"score_spread":0.2265839312746643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}