{"id":"W4413453280","doi":"10.3802/jgo.2026.37.e9","title":"Efficacy and toxicity of PARP inhibitor in elderly patients with homologous recombination-deficient newly diagnosed advanced ovarian cancer: the role of dose modification","year":2025,"lang":"en","type":"article","venue":"Journal of Gynecologic Oncology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Ministry of Health and Welfare","keywords":"Medicine; PARP inhibitor; Ovarian cancer; Homologous recombination; Toxicity; Homologous chromosome; Oncology; Poly ADP ribose polymerase; Internal medicine; Cancer; Pharmacology; Genetics; DNA; Polymerase; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001373582,0.000108807,0.0004377117,0.0001981693,0.0001063505,0.0003015044,0.0001386673,0.0001948315,0.0003273589],"category_scores_gemma":[0.003294882,0.00006929971,0.0004821201,0.0002989712,0.0001398293,0.0003071056,0.0001663327,0.0002485334,0.00005161287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003379298,"about_ca_system_score_gemma":0.0002117329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004429773,"about_ca_topic_score_gemma":0.0008038883,"domain_scores_codex":[0.9995186,0.0001901079,0.00007163183,0.00007462105,0.0001017142,0.00004325222],"domain_scores_gemma":[0.997291,0.0007538957,0.001619593,0.00009589754,0.00009749693,0.0001421115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002606026,0.00006141252,0.9792285,0.00004197658,0.0002282365,0.0001293812,0.0000414233,0.0004492429,0.001245854,0.00002556585,0.00005258434,0.01588972],"study_design_scores_gemma":[0.00007765722,0.002200507,0.9951569,0.00001487892,0.000175867,0.000594464,0.00004174138,0.0006348987,0.0005796602,0.0000355718,0.0004835973,0.000004269164],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971,0.002421512,0.0001085693,0.00003804503,0.000004659479,0.000007420654,0.00008710521,0.000001764344,0.0002309216],"genre_scores_gemma":[0.9993025,0.0004242819,0.00007951374,0.00003458064,0.00001536208,0.000004421116,0.00008872049,6.566277e-7,0.00004992451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001373582,"threshold_uncertainty_score":0.007264316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01131643990735361,"score_gpt":0.3096241683581557,"score_spread":0.2983077284508021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}