{"id":"W4413460573","doi":"10.1093/ibd/izaf181","title":"Rewiring of Transcription Factor Binding: Another Piece of the Intricate Puzzle of IBD Pathogenesis","year":2025,"lang":"en","type":"article","venue":"Inflammatory Bowel Diseases","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Pathogenesis; Transcription factor; Medicine; Computational biology; Cancer research; Biology; Genetics; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002122154,0.0008331228,0.001459403,0.0006094809,0.001062916,0.00262335,0.001842807,0.004915894,0.003328794],"category_scores_gemma":[0.00279909,0.0003186964,0.001294466,0.000516771,0.003905439,0.004678291,0.001587032,0.00926329,0.001667949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001833136,"about_ca_system_score_gemma":0.00222339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002007985,"about_ca_topic_score_gemma":0.004322167,"domain_scores_codex":[0.9984038,0.0004621585,0.0001574516,0.0003880281,0.0003018799,0.0002866943],"domain_scores_gemma":[0.9989009,0.0005720981,0.00009694548,0.00007993515,0.0002167829,0.0001332689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0009504774,0.0001113373,0.002366045,0.007885233,0.0002870683,0.003039431,0.006878817,0.001437026,0.06417747,0.1719413,0.2968902,0.4440356],"study_design_scores_gemma":[0.0000466972,0.00016958,0.00138487,0.001208705,0.00005578412,0.001237314,0.001551096,0.000362776,0.003955377,0.04789386,0.9420816,0.00005245078],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.00466347,0.7217757,0.008635484,0.2092547,0.04887139,0.00002749833,0.000120822,0.0001800526,0.006470917],"genre_scores_gemma":[0.05423388,0.7039933,0.005777615,0.1236717,0.08334568,0.00009706381,0.0003143299,0.0001700968,0.02839632],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004915894,"threshold_uncertainty_score":0.01330042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008864474234517045,"score_gpt":0.2154414423216321,"score_spread":0.206576968087115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}