{"id":"W4413460573","doi":"10.1093/ibd/izaf181","title":"Rewiring of Transcription Factor Binding: Another Piece of the Intricate Puzzle of IBD Pathogenesis","year":2025,"lang":"en","type":"article","venue":"Inflammatory Bowel Diseases","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Pathogenesis; Transcription factor; Medicine; Computational biology; Cancer research; Biology; Genetics; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009914655,0.0001433463,0.0002726412,0.000165051,0.0001229374,0.00000367517,0.0003772987,0.0001210774,0.0001581563],"category_scores_gemma":[0.00009853215,0.0001094155,0.0002559057,0.0002647211,0.0004218594,0.0000827465,0.00006559204,0.0000932926,0.00000740782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001741455,"about_ca_system_score_gemma":0.0001144124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003219546,"about_ca_topic_score_gemma":0.00000229181,"domain_scores_codex":[0.9989141,0.0001613803,0.0005156674,0.0001668058,0.00005509962,0.0001868946],"domain_scores_gemma":[0.9991077,0.00008582794,0.0003074259,0.0004057359,0.00008928002,0.00000404892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001897021,0.0002149505,0.05777837,0.0003298747,0.0001560165,4.874469e-7,0.0005184594,0.000050844,0.9350565,0.0007285203,0.00005404363,0.004922222],"study_design_scores_gemma":[0.0006485113,0.00002082032,0.5398196,0.0002117451,0.000113115,5.187136e-7,0.0003340865,0.000004006235,0.4561098,0.00007921051,0.002565154,0.00009346617],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780695,0.02041502,0.00007537675,0.00005590413,0.0004402266,0.0002421836,0.0001976274,0.00002743938,0.0004767221],"genre_scores_gemma":[0.9991393,0.0001389597,0.000003073968,0.00002581299,0.000001366916,0.00001557249,0.000013875,0.0000104132,0.0006516287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4820412,"threshold_uncertainty_score":0.4461834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008864474234517045,"score_gpt":0.2154414423216321,"score_spread":0.206576968087115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}