{"id":"W4413466229","doi":"10.1016/j.pnpbp.2025.111478","title":"A novel cannabidiol:tetramethylpyrazine cocrystal (CBD:TMP, ART12.11) improves the efficacy and bioavailability of cannabidiol in reducing stress-induced depressive and anxiety symptoms","year":2025,"lang":"en","type":"article","venue":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Western University; Lawson Health Research Institute","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"Cannabidiol; Tetramethylpyrazine; Anxiety; Bioavailability; Pharmacology; Medicine; Cocrystal; Chemistry; Psychiatry; Organic chemistry; Cannabis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007323682,0.0002103001,0.000318424,0.0002410808,0.000147225,0.0002133266,0.0003101359,0.0002684378,0.001253285],"category_scores_gemma":[0.0000933379,0.0001097758,0.0002279718,0.0001457412,0.0001616732,0.0001947279,0.0001435882,0.0005338699,0.000196347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003017066,"about_ca_system_score_gemma":0.0001763761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001686938,"about_ca_topic_score_gemma":0.003476173,"domain_scores_codex":[0.999934,0.000006863539,0.000005251819,0.00001764774,0.00002666812,0.000009596567],"domain_scores_gemma":[0.9999659,0.000004663682,0.00001196972,0.000002777661,0.000005616689,0.000009127304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004409432,0.0001425863,0.0001023094,0.0001823933,0.00002129135,0.00009081939,0.00001738537,0.0002812248,0.9902093,0.0001522287,0.0002361891,0.008123397],"study_design_scores_gemma":[0.0001122324,0.001492215,0.002208593,0.00001925426,0.00009268155,0.0004164795,0.00002255734,0.003018686,0.9870381,0.00003953236,0.005518939,0.00002062494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888608,0.003409678,0.004000169,0.0001868404,0.00004977712,0.00007663493,0.00054371,0.0001842557,0.002688202],"genre_scores_gemma":[0.9874001,0.00226468,0.006376695,0.00009454852,0.00001415939,0.00004982318,0.0004726305,0.00003220688,0.003295356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001686938,"threshold_uncertainty_score":0.00419265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01561151835320517,"score_gpt":0.3346469582130336,"score_spread":0.3190354398598285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}