{"id":"W4413471239","doi":"10.1101/2025.08.22.671758","title":"Photochemical modification of two fluorene-based molecules yields structurally distinct DNA intercalators with potent anti-MRSA activity","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Regina; Western University","funders":"Canadian Institutes of Health Research; Saskatchewan Health Research Foundation; McMaster University","keywords":"Fluorene; Intercalation (chemistry); Chemistry; DNA; Molecule; Photochemistry; Small molecule; Combinatorial chemistry; Biochemistry; Organic chemistry; Polymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008592081,0.0003004129,0.0001429497,0.0001223688,0.00006623929,0.0001204077,0.0001886668,0.0002712182,0.000983641],"category_scores_gemma":[0.000116583,0.00009272817,0.000202462,0.0001164673,0.0001194542,0.0001441029,0.0001515002,0.0002330652,0.000232483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001804005,"about_ca_system_score_gemma":0.0001056507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004106073,"about_ca_topic_score_gemma":0.0006166324,"domain_scores_codex":[0.9999299,0.000008023416,0.000004473325,0.00001805329,0.00001425097,0.00002518064],"domain_scores_gemma":[0.9999427,0.000009297952,0.00002296135,0.000005754715,0.000007886142,0.00001138505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006565529,0.00001968476,0.000061884,0.00003533345,0.000004293037,0.00002522807,0.000006071128,0.0001276937,0.9983227,0.0000452101,0.00001598884,0.001270251],"study_design_scores_gemma":[0.00001001283,0.0005980777,0.0006920265,0.000003744713,0.000007710159,0.0001124666,0.000007351186,0.0002939907,0.9973231,0.00001027332,0.0009366663,0.000004659295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945819,0.001238314,0.002631798,0.00003933434,0.0000144583,0.00002317084,0.0001689552,0.00004288986,0.001259236],"genre_scores_gemma":[0.9959027,0.0005822314,0.002150621,0.00003502711,0.000002273204,0.00001382219,0.0001872742,0.000007473886,0.001118641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000983641,"threshold_uncertainty_score":0.003290653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008303582357663333,"score_gpt":0.2266540327641871,"score_spread":0.2183504504065238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}