{"id":"W4413472568","doi":"10.1101/2025.08.21.671625","title":"α-catenin phosphorylation is actomyosin-sensitive and required for epithelial barrier functions through Afadin","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"National Center for Research Resources; National Cancer Institute; National Eye Institute; Tokyo Metropolitan University; National Heart, Lung, and Blood Institute; Princess Margaret Cancer Foundation; Northwestern University","keywords":"Catenin; Phosphorylation; Chemistry; Cell biology; Biophysics; Biology; Signal transduction; Wnt signaling pathway","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004616386,0.0004514745,0.0004091629,0.000119824,0.0002839077,0.0001036487,0.0002857124,0.001051877,0.00002603659],"category_scores_gemma":[0.0003055097,0.0004781615,0.0002144251,0.0001863517,0.0002755793,0.00001100711,0.0005205845,0.0004001241,0.00001731219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007011706,"about_ca_system_score_gemma":0.0006241373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003800915,"about_ca_topic_score_gemma":0.000003431361,"domain_scores_codex":[0.9975922,0.0001540389,0.0003623864,0.001207493,0.0001706491,0.0005132306],"domain_scores_gemma":[0.9981808,0.00005708667,0.0001935221,0.0008081747,0.0006029404,0.0001574692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002908883,0.00005675038,0.0008733266,0.0001334375,0.0003352883,0.000007631181,0.0000168018,0.000005178235,0.9950983,0.000157861,0.003015692,0.000008861621],"study_design_scores_gemma":[0.0008283048,0.0001446474,0.00311121,0.00009968335,0.0001297695,7.833579e-8,0.00001035493,0.0001406842,0.9550077,0.00001032451,0.04001866,0.0004986277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9704766,0.003559784,0.01955955,0.0005455895,0.001265534,0.001571341,0.002833631,0.000084066,0.0001039506],"genre_scores_gemma":[0.9938179,0.001029397,0.003073006,0.0004195764,0.0006423084,0.0003936261,0.00002101439,0.00006490455,0.0005382145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04009063,"threshold_uncertainty_score":0.999767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01703042700175697,"score_gpt":0.2576429279304874,"score_spread":0.2406125009287305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}