{"id":"W4413473130","doi":"10.1101/2025.08.21.671483","title":"In vitro and in vivo activity profiles of broad-spectrum bacterial ATP synthase inhibitors","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Cystic Fibrosis Canada","keywords":"Staphylococcus aureus; Acinetobacter baumannii; Microbiology; Escherichia coli; In vivo; Antibacterial activity; Antimicrobial; Bacteria; In vitro; Antibiotics; Biology; Chemistry; Biochemistry; Pseudomonas aeruginosa","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005077965,0.0005024872,0.000676266,0.0003292969,0.00005799364,0.00007000948,0.0004173377,0.000739189,0.00002727279],"category_scores_gemma":[0.000216476,0.0005560885,0.0001582661,0.0003646619,0.000229884,0.00001932297,0.001025796,0.0005949055,0.000002429573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000982719,"about_ca_system_score_gemma":0.000809789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002922224,"about_ca_topic_score_gemma":0.00003073123,"domain_scores_codex":[0.9972124,0.0002343712,0.000529114,0.001135649,0.0002843648,0.0006040779],"domain_scores_gemma":[0.9984351,0.0000553129,0.0002639225,0.0009470402,0.0001227549,0.0001758616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007432798,0.0002934418,0.002810858,0.0005830979,0.00006945305,0.00005269965,0.00000473219,0.00001335685,0.9951272,0.00001557446,0.0002802985,0.000005978472],"study_design_scores_gemma":[0.0008716375,0.00007673682,0.003783897,0.0003705229,0.00002737937,1.62082e-8,0.000002558797,0.00007138077,0.9895069,9.465321e-7,0.004806542,0.0004814851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961831,0.001010585,0.00007346719,0.0002619328,0.0004995248,0.0007760845,0.001143559,0.00002755964,0.00002419095],"genre_scores_gemma":[0.9979252,0.0008436351,0.0004456665,0.00007906256,0.0004375855,0.0001841121,0.000001752136,0.00005889399,0.00002409583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005620333,"threshold_uncertainty_score":0.999689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00865301484263186,"score_gpt":0.2423699094520989,"score_spread":0.233716894609467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}