{"id":"W4413495371","doi":"10.1038/s41594-025-01652-z","title":"Evolutionary analysis reveals the origin of sodium coupling in glutamate transporters","year":2025,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institutes of Health; Howard Hughes Medical Institute; Agouron Institute; Weill Cornell Medical College; York University","keywords":"Excitatory amino-acid transporter; Transporter; Sodium Glutamate; Glutamate receptor; Sodium; Coupling (piping); Chemistry; Biophysics; Biochemistry; Cell biology; Biology; Gene; Materials science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007283571,0.0002917409,0.0003897409,0.0008414817,0.0006074564,0.0007540481,0.0003400999,0.0007966411,0.000650129],"category_scores_gemma":[0.001210067,0.0002783211,0.0004019534,0.0007429779,0.0008432882,0.0008194455,0.0007139056,0.0008624166,0.0002865444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006461054,"about_ca_system_score_gemma":0.0002895446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006935602,"about_ca_topic_score_gemma":0.001050392,"domain_scores_codex":[0.9997053,0.00008898313,0.00001949859,0.00009242701,0.00004884576,0.00004494496],"domain_scores_gemma":[0.9996475,0.0001118074,0.00006621432,0.00005577177,0.00006918975,0.00004942491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009495229,0.00009969243,0.07580271,0.0002550345,0.0002088367,0.002486245,0.001618764,0.02011943,0.8310192,0.01654451,0.0002302105,0.05066581],"study_design_scores_gemma":[0.00008145846,0.0008691389,0.58749,0.0001891742,0.0004278005,0.006850522,0.002053368,0.1729881,0.1717654,0.0286111,0.02836118,0.0003129025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861823,0.0005245834,0.01115305,0.0001709739,0.000009116219,0.000008736318,0.00006801455,0.00006105466,0.001822119],"genre_scores_gemma":[0.9944285,0.0004436283,0.004657555,0.00005228857,0.000007847861,0.000004753821,0.0001212511,0.00002697925,0.000257288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008414817,"threshold_uncertainty_score":0.004687786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004213439946636433,"score_gpt":0.2792381517653978,"score_spread":0.2750247118187614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}