{"id":"W4413500350","doi":"10.1128/msphere.00308-25","title":"Unc-51-like kinase 1 (ULK1) regulates bacterial ubiquitylation and p62 recruitment during xenophagic clearance of <i>Listeria monocyt</i> ogenes","year":2025,"lang":"en","type":"article","venue":"mSphere","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"ULK1; Autophagy; Cell biology; Intracellular parasite; Biology; Intracellular; Signal transducing adaptor protein; Ubiquitin; Listeria monocytogenes; Protein kinase A; Kinase; Phosphorylation; Microbiology; Bacteria; Biochemistry; Genetics; AMPK; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008636837,0.0001701552,0.0003211546,0.00004539985,0.00008868212,0.00002384495,0.00007287825,0.0001044411,0.0004104714],"category_scores_gemma":[0.00001343387,0.000155712,0.00007405304,0.0001608171,0.00008160547,0.0000928058,0.00006105841,0.00007142556,0.000009246309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005877058,"about_ca_system_score_gemma":0.00006769994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003765118,"about_ca_topic_score_gemma":0.0000149349,"domain_scores_codex":[0.9990463,0.00004744322,0.0002984748,0.000283082,0.0001382542,0.000186414],"domain_scores_gemma":[0.9993895,0.00002516228,0.0001069966,0.0003345431,0.00006254957,0.00008123875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004928528,0.0004223935,0.01168115,0.001298261,0.0003739838,0.00009706177,0.0006289058,0.00004160653,0.9432293,0.0006188569,0.0007186313,0.03596129],"study_design_scores_gemma":[0.00472868,0.000269025,0.3580677,0.0006750718,0.0002137183,0.00001861309,0.000170892,0.0001508061,0.6264409,0.001202741,0.007846824,0.000214997],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923494,0.005209474,0.0000199508,0.0002338807,0.00035483,0.000566719,0.00001773965,0.00006296571,0.001185081],"genre_scores_gemma":[0.9956198,0.0003838578,0.000336844,0.0002388654,0.0001364597,0.00004624267,0.00003351465,0.00002024365,0.003184213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3463866,"threshold_uncertainty_score":0.6349753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02264913671307887,"score_gpt":0.2948647866020238,"score_spread":0.2722156498889449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}