{"id":"W4413500350","doi":"10.1128/msphere.00308-25","title":"Unc-51-like kinase 1 (ULK1) regulates bacterial ubiquitylation and p62 recruitment during xenophagic clearance of <i>Listeria monocyt</i> ogenes","year":2025,"lang":"en","type":"article","venue":"mSphere","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"ULK1; Autophagy; Cell biology; Intracellular parasite; Biology; Intracellular; Signal transducing adaptor protein; Ubiquitin; Listeria monocytogenes; Protein kinase A; Kinase; Phosphorylation; Microbiology; Bacteria; Biochemistry; Genetics; AMPK; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001117505,0.0001806989,0.0001973577,0.0001072165,0.0002240266,0.0003455438,0.0001242891,0.000252565,0.0008306365],"category_scores_gemma":[0.00009215509,0.0001139178,0.0001533805,0.00009638527,0.0001839108,0.0001502634,0.0001733931,0.000328386,0.0004064204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004527353,"about_ca_system_score_gemma":0.0001876269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008028911,"about_ca_topic_score_gemma":0.0009312428,"domain_scores_codex":[0.9998838,0.00001684056,0.00001054477,0.00002531329,0.00001809198,0.00004543181],"domain_scores_gemma":[0.9999231,0.00001000945,0.00002907911,0.000007774106,0.000007492416,0.00002248766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002460665,0.00001736905,0.0003810087,0.00002806083,0.000002050936,0.00005637713,0.00001415605,0.00004350587,0.9986814,0.00007369307,0.00005064764,0.0004057176],"study_design_scores_gemma":[0.00002061321,0.00012526,0.02180606,0.000009015487,0.000008228979,0.0002061393,0.00008164992,0.001257694,0.974956,0.00006576196,0.001457578,0.000006022471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969354,0.001095208,0.000813473,0.00007702241,0.00001576637,0.000007335689,0.0003052123,0.00003485902,0.0007156986],"genre_scores_gemma":[0.9977209,0.000315008,0.0005163109,0.00004784387,0.000003985345,0.000010145,0.0003210308,0.0000110347,0.001053693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008306365,"threshold_uncertainty_score":0.003284872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02264913671307887,"score_gpt":0.2948647866020238,"score_spread":0.2722156498889449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}