{"id":"W4413504326","doi":"10.1101/2025.08.19.671129","title":"IRP1 deficiency alters mitochondrial metabolism and protects against metabolic syndrome pathologies","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University; Université de Montréal; McGill University","funders":"Deutsche Forschungsgemeinschaft; University of Alberta; Canadian Institutes of Health Research; Deutsches Krebsforschungszentrum","keywords":"Metabolism; Metabolic syndrome; Mitochondrion; Medicine; Bioinformatics; Biology; Physiology; Endocrinology; Cell biology; Obesity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001472745,0.0004680009,0.000344854,0.0004892356,0.0001727775,0.0003114815,0.0003071507,0.0004274321,0.002710798],"category_scores_gemma":[0.000124163,0.0001272962,0.0001580183,0.0002079122,0.0002948671,0.0001871935,0.0002318427,0.0006789002,0.0005472315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000199322,"about_ca_system_score_gemma":0.00011312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002745371,"about_ca_topic_score_gemma":0.0002577458,"domain_scores_codex":[0.9999195,0.00001318637,0.000005839733,0.00002566869,0.00001780898,0.00001804238],"domain_scores_gemma":[0.9998758,0.00001230928,0.00004052438,0.00001491422,0.00001056465,0.00004588161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008936119,0.00006317803,0.0005304259,0.00004211732,0.00001646219,0.0001014661,0.00001214638,0.00007956196,0.9950038,0.0001278644,0.0002428787,0.002886431],"study_design_scores_gemma":[0.0001120732,0.0006578134,0.01986664,0.00003355058,0.00004830099,0.0006746324,0.00005301888,0.001088498,0.9716409,0.0003110267,0.005502418,0.0000111165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926761,0.001970458,0.00194371,0.000350191,0.00006986066,0.00001445241,0.001468452,0.0002408457,0.001266075],"genre_scores_gemma":[0.9922883,0.0008500324,0.001361837,0.0001233131,0.00002141198,0.00002726376,0.001759989,0.00008820225,0.003479635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002710798,"threshold_uncertainty_score":0.009068489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01102772248547641,"score_gpt":0.2200863569328622,"score_spread":0.2090586344473858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}