{"id":"W4413508941","doi":"10.1001/jamaneurol.2025.2974","title":"Concurrent Changes in Plasma Phosphorylated Tau 217, Tau PET, and Cognition in Preclinical Alzheimer Disease","year":2025,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging","keywords":"Asymptomatic; Medicine; Positron emission tomography; Internal medicine; Disease; Neurodegeneration; Alzheimer's disease; Longitudinal study; Pittsburgh compound B; Alzheimer's Disease Neuroimaging Initiative; Cognition; Standardized uptake value; Amyloid (mycology); Oncology; Cognitive decline; Psychology; Dementia; Pathology; Nuclear medicine; Psychiatry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002280322,0.0004512704,0.0004552671,0.0006774847,0.0004209256,0.0007380403,0.0003768697,0.0006469489,0.001307548],"category_scores_gemma":[0.004967425,0.0002603433,0.0003595336,0.0007847385,0.0004694324,0.0008030912,0.0003678367,0.0005990943,0.0002397911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003756231,"about_ca_system_score_gemma":0.0004762597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001246234,"about_ca_topic_score_gemma":0.001999819,"domain_scores_codex":[0.999243,0.0003018793,0.00008968385,0.0001335387,0.0001718461,0.00005998051],"domain_scores_gemma":[0.997726,0.0005380185,0.001170884,0.0001286799,0.0002311809,0.0002052435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002335882,0.0001747021,0.9911055,0.00004606664,0.0001862361,0.0001193289,0.00005076201,0.00009006423,0.0009688594,0.00002823293,0.0001214218,0.004772934],"study_design_scores_gemma":[0.00006453229,0.0008676245,0.9975695,0.00001156044,0.0001063535,0.000458399,0.0000461459,0.0001622521,0.0003620053,0.0001405066,0.0002059827,0.000005116839],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973112,0.001386493,0.0001503308,0.00008551044,0.00001121345,0.00001999139,0.0002916087,0.000008039687,0.0007356369],"genre_scores_gemma":[0.9990712,0.0002202586,0.0002143876,0.00003974454,0.00002649871,0.0000182718,0.0002428869,0.000001764376,0.0001650697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002280322,"threshold_uncertainty_score":0.01205963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03377173604215999,"score_gpt":0.3571164391013627,"score_spread":0.3233447030592027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}