{"id":"W4413599198","doi":"10.1080/27694127.2025.2547975","title":"Sequestering sequestosome 1 via S-acylation in autophagy, Huntington disease, and beyond","year":2025,"lang":"en","type":"article","venue":"Autophagy Reports","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Sequestosome 1; Neurodegeneration; Autophagy; Cell biology; Protein aggregation; Proteostasis; Biology; Huntington's disease; Chemistry; Biochemistry; Medicine; Disease; Internal medicine; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000136805,0.0002187967,0.0002379804,0.0003421713,0.0002111744,0.0003340451,0.0001235403,0.0003842586,0.0005595704],"category_scores_gemma":[0.00004942797,0.00006109939,0.0001539106,0.0002234871,0.0003282189,0.0003708148,0.0002891129,0.0003356908,0.0001811633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003458103,"about_ca_system_score_gemma":0.0002213832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004961963,"about_ca_topic_score_gemma":0.0008956288,"domain_scores_codex":[0.9999678,0.000005907717,0.000003901717,0.000007142436,0.000008385562,0.000006830626],"domain_scores_gemma":[0.9999776,0.000003043089,0.000006182998,0.000001873172,0.000003892456,0.000007393308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001292874,0.0002955534,0.004104089,0.001607421,0.0000587776,0.005382136,0.0004285937,0.0006850032,0.7906752,0.01833718,0.006566414,0.1705666],"study_design_scores_gemma":[0.0002177484,0.002552029,0.05263675,0.0005650451,0.0002795928,0.02358404,0.000621793,0.003733764,0.6133724,0.0250906,0.2772474,0.00009891018],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.4761803,0.5011962,0.003983442,0.003011443,0.0004509642,0.00005069653,0.0002134232,0.0001824655,0.01473109],"genre_scores_gemma":[0.8548238,0.1344599,0.001828279,0.0008293515,0.0002438256,0.00003492056,0.0002295505,0.0000091272,0.007541225],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0005595704,"threshold_uncertainty_score":0.002509058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008135600404960123,"score_gpt":0.2818925959365832,"score_spread":0.2737569955316231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}