{"id":"W4413612243","doi":"10.3389/fimmu.2025.1644783","title":"MicroRNA-132 regulates quinolinic acid production in the brain during LPS-induced neuroinflammation","year":2025,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada","keywords":"Quinolinic acid; Neuroinflammation; microRNA; Chemistry; Cell biology; Neuroscience; Medicine; Biology; Inflammation; Immunology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001444595,0.0003544792,0.0003027052,0.0002012028,0.0002132286,0.0003415937,0.0001275879,0.0002688409,0.001123184],"category_scores_gemma":[0.0001820022,0.0001513735,0.000215106,0.0001176638,0.0002958513,0.0001918605,0.0002071966,0.0004958729,0.0004476014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003022317,"about_ca_system_score_gemma":0.0003204794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000344473,"about_ca_topic_score_gemma":0.0005622617,"domain_scores_codex":[0.9998354,0.00002120286,0.00001497253,0.0000462624,0.0000425874,0.00003951486],"domain_scores_gemma":[0.9998975,0.00000901605,0.00004210261,0.000005093334,0.00002072399,0.0000256373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005195959,0.00003223871,0.0006183237,0.0000909336,0.000008488777,0.0000984992,0.00003784824,0.00006760983,0.9960073,0.0001556271,0.0001595125,0.002204183],"study_design_scores_gemma":[0.00007807341,0.0008567123,0.04081498,0.00004132272,0.00009640127,0.001008083,0.0001922657,0.002773574,0.9436126,0.0004356189,0.01006315,0.0000272435],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846711,0.0041656,0.005955791,0.0003055721,0.0001483038,0.00006169745,0.0009386052,0.0002645455,0.003488777],"genre_scores_gemma":[0.9908269,0.001461765,0.00415253,0.0001597073,0.00003154505,0.0001201386,0.0005841884,0.00005099745,0.00261229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001123184,"threshold_uncertainty_score":0.003757417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01314472407423733,"score_gpt":0.2440710555893063,"score_spread":0.230926331515069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}