{"id":"W4413619310","doi":"10.3390/cells14171314","title":"Calpain-1 and Calpain-2 Promote Breast Cancer Metastasis","year":2025,"lang":"en","type":"article","venue":"Cells","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Queen's University; Canadian Institutes of Health Research; University of Arizona Cancer Center","keywords":"Calpain; Metastasis; Breast cancer; Breast cancer metastasis; Medicine; Cancer metastasis; Cancer; Cancer research; Oncology; Internal medicine; Biology; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001317449,0.000418727,0.000321649,0.0002038475,0.0001362829,0.0003716148,0.0001665201,0.0003516306,0.001637559],"category_scores_gemma":[0.0001216696,0.0001483143,0.0003269294,0.0001041291,0.0001743496,0.0002403934,0.0002305742,0.0007604357,0.0002613149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002416142,"about_ca_system_score_gemma":0.0002100865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008173453,"about_ca_topic_score_gemma":0.001645044,"domain_scores_codex":[0.9998491,0.00001724515,0.00000957292,0.00003430268,0.00005385022,0.00003594177],"domain_scores_gemma":[0.99991,0.00001195261,0.0000288624,0.000007013416,0.00001208324,0.00003018969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001006863,0.00006129758,0.0002128514,0.00004762219,0.00000655584,0.00003600225,0.0000112335,0.00003914382,0.9974111,0.00006113172,0.000104415,0.001907936],"study_design_scores_gemma":[0.00004995075,0.0008873767,0.01664687,0.00001275254,0.00002434744,0.0006123869,0.00004174751,0.0009659966,0.9754418,0.00009709272,0.00521268,0.00000695569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854042,0.00790327,0.002911521,0.0003002097,0.0001042027,0.00005394015,0.0003203435,0.0001855243,0.002816775],"genre_scores_gemma":[0.9914038,0.0027041,0.001762137,0.0001192049,0.00002647309,0.00002825209,0.000321482,0.00001382705,0.0036207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001637559,"threshold_uncertainty_score":0.005478144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003713294166713114,"score_gpt":0.2350933886045419,"score_spread":0.2313800944378288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}