{"id":"W4413619310","doi":"10.3390/cells14171314","title":"Calpain-1 and Calpain-2 Promote Breast Cancer Metastasis","year":2025,"lang":"en","type":"article","venue":"Cells","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Queen's University; Canadian Institutes of Health Research; University of Arizona Cancer Center","keywords":"Calpain; Metastasis; Breast cancer; Breast cancer metastasis; Medicine; Cancer metastasis; Cancer; Cancer research; Oncology; Internal medicine; Biology; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001389589,0.0001026987,0.00009344189,0.00004135588,0.00008122107,0.00002229518,0.00005249965,0.000101016,0.00009147887],"category_scores_gemma":[0.00001201005,0.00008924227,0.00005154477,0.00009275696,0.00006484916,0.000002174332,0.00005994225,0.00005233425,0.000006430736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000151397,"about_ca_system_score_gemma":0.00006336402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000511268,"about_ca_topic_score_gemma":0.00003097336,"domain_scores_codex":[0.9993853,0.00004859088,0.0001134321,0.0002554985,0.00006089042,0.0001362965],"domain_scores_gemma":[0.9996677,0.000006155038,0.0000319694,0.0001751,0.00005869496,0.0000603739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008042934,0.00004578421,0.0009870285,0.00006583381,0.00009433722,0.00000156563,0.00002456748,0.00005598339,0.9235827,0.0001779465,0.02136873,0.05351514],"study_design_scores_gemma":[0.0006153674,0.00004256737,0.006971146,0.00003565396,0.00006304126,0.00001071935,0.00004379592,0.0004264482,0.5885713,0.0001367615,0.4028901,0.0001930975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97864,0.003410388,0.01016005,0.003298697,0.0007738821,0.0006136813,0.0001283067,0.00004759724,0.002927427],"genre_scores_gemma":[0.9808814,0.000306395,0.0003227275,0.001032877,0.0001653627,0.00004388903,0.00004432427,0.00001289945,0.01719015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3815214,"threshold_uncertainty_score":0.3639194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003713294166713114,"score_gpt":0.2350933886045419,"score_spread":0.2313800944378288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}