{"id":"W4413637300","doi":"10.1172/jci.insight.189601","title":"The spleen tyrosine kinase inhibitor entospletinib resolves inflammation to promote repair following acute kidney injury","year":2025,"lang":"en","type":"article","venue":"JCI Insight","topic":"Acute Kidney Injury Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canterbury Medical Research Foundation; University of Calgary","keywords":"Inflammation; Acute kidney injury; Tyrosine-kinase inhibitor; Kidney; Spleen; Tyrosine kinase; Medicine; Cancer research; Tissue repair; Bruton's tyrosine kinase; Kinase; Pharmacology; Internal medicine; Biology; Cell biology; Cancer; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008959696,0.000314116,0.0004299266,0.0004070209,0.0005246348,0.0001570263,0.000365798,0.0002124868,0.0000968603],"category_scores_gemma":[0.003109678,0.0002191144,0.0003187743,0.001288373,0.0001087345,0.0002464378,0.0004564786,0.00056601,0.0002894065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000316198,"about_ca_system_score_gemma":0.0007794229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003784991,"about_ca_topic_score_gemma":0.000007351295,"domain_scores_codex":[0.9970784,0.0001544007,0.0006810964,0.0005853304,0.0008413021,0.0006594735],"domain_scores_gemma":[0.9976811,0.0001301388,0.0001057303,0.001153451,0.0003074571,0.0006220707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001345058,0.0001224787,0.003084564,0.0001257694,0.0005117849,0.0001936329,0.0008074103,1.143594e-7,0.2214864,0.001196098,0.7621983,0.008928439],"study_design_scores_gemma":[0.001231541,0.0005170486,0.00262364,0.0004678249,0.0001986421,0.000006935397,0.00004290034,0.0001239454,0.1982194,0.0001217012,0.7962656,0.0001807497],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7806524,0.0004197331,0.0003224269,0.1651544,0.002316493,0.004864649,0.0003162934,0.0009515802,0.04500205],"genre_scores_gemma":[0.8235126,0.0004520531,0.0120484,0.02154179,0.003599366,0.001726639,0.001019147,0.0002555119,0.1358445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1436126,"threshold_uncertainty_score":0.8935226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01305427464661082,"score_gpt":0.3227440765023588,"score_spread":0.309689801855748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}