{"id":"W4413641730","doi":"10.1186/s12915-025-02366-w","title":"Understanding the traits underlying vaccine-driven virulence evolution in malaria parasites","year":2025,"lang":"en","type":"article","venue":"BMC Biology","topic":"Malaria Research and Control","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Virulence; Vaccination; Parasite hosting; Malaria vaccine; Malaria; Immune system; Vaccine efficacy; Immunity; Immunology; Antigenic variation; Host (biology); Experimental evolution; Virology; Plasmodium falciparum; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009637631,0.0003316683,0.0003208943,0.0002401469,0.0001575091,0.0004872267,0.0003256907,0.0005704644,0.0008953256],"category_scores_gemma":[0.003909489,0.0001719499,0.0004245779,0.0002012276,0.0004246979,0.0006800476,0.000301725,0.0007280934,0.000133561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008126415,"about_ca_system_score_gemma":0.0004227857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00142998,"about_ca_topic_score_gemma":0.001526009,"domain_scores_codex":[0.9996957,0.0001044792,0.00001678205,0.00009517733,0.00004380268,0.00004399568],"domain_scores_gemma":[0.9985284,0.0007496793,0.0004685632,0.0001059344,0.00008538063,0.0000621284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004052765,0.0002451913,0.183619,0.0005953028,0.000343208,0.00018158,0.0003954231,0.3519959,0.4149751,0.01479901,0.0006516658,0.0317933],"study_design_scores_gemma":[0.00002173225,0.0004641334,0.2986716,0.00004698251,0.000129653,0.0002675445,0.0001204463,0.6553229,0.02997801,0.0131072,0.001807885,0.00006186846],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.963129,0.000235105,0.03545489,0.0001685571,0.000006485678,0.00001663792,0.0003705026,0.00005470009,0.000564145],"genre_scores_gemma":[0.9940857,0.0001097711,0.005399955,0.00002750821,0.000003453934,0.0000148315,0.0002194125,0.00001691842,0.0001225692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00142998,"threshold_uncertainty_score":0.005896091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.106103037792843,"score_gpt":0.3585984519638039,"score_spread":0.2524954141709609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}