{"id":"W4413680771","doi":"10.1172/jci.insight.194314","title":"The role of complement in long COVID pathogenesis","year":2025,"lang":"en","type":"review","venue":"JCI Insight","topic":"Long-Term Effects of COVID-19","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Yale University; U.S. Department of Veterans Affairs","keywords":"Pathogenesis; Immunology; Coronavirus disease 2019 (COVID-19); Disease; Complement system; Inflammation; Medicine; Immune system; Immune dysregulation; Innate immune system; Malaise; Pathology; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005968795,0.0004736737,0.0007253889,0.001833257,0.0002753571,0.001151197,0.0005295976,0.0009477838,0.003190377],"category_scores_gemma":[0.0007941649,0.0001624922,0.0004000526,0.00147603,0.0004055966,0.0009884989,0.0006960011,0.001292477,0.001170066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006659257,"about_ca_system_score_gemma":0.001424639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001439611,"about_ca_topic_score_gemma":0.002355,"domain_scores_codex":[0.9998302,0.00002988321,0.00002596729,0.00002292606,0.00006766918,0.00002325463],"domain_scores_gemma":[0.9997188,0.0001082848,0.00004218494,0.000007797843,0.00009207538,0.00003069435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007698384,0.0000414041,0.000320866,0.01549216,0.0001106151,0.000335384,0.0001058612,0.0002452246,0.001908312,0.005478316,0.03142941,0.9444554],"study_design_scores_gemma":[0.00001343837,0.00007647346,0.001082923,0.005566144,0.00009883885,0.001500739,0.00009216299,0.0000698978,0.0004169068,0.002009089,0.9890562,0.00001712005],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001102567,0.9986221,0.000054596,0.0002815718,0.0001511896,0.00000272456,0.00001217951,0.00000356438,0.000761927],"genre_scores_gemma":[0.0007125143,0.9985803,0.00008762081,0.0001470647,0.0001158828,0.000003649249,0.00001915408,6.905303e-7,0.0003330449],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003190377,"threshold_uncertainty_score":0.01067287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02846532688377494,"score_gpt":0.3580209435946415,"score_spread":0.3295556167108666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}