{"id":"W4413707184","doi":"10.1101/2025.08.18.670902","title":"Pyrimethamine inhibits mutant NRF2 as a molecular glue","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Institutes of Health","keywords":"GLUE; Mutant; Pyrimethamine; Chemistry; Biology; Malaria; Immunology; Biochemistry; Materials science; Gene; Plasmodium falciparum","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001276399,0.0002952731,0.0002248201,0.0001361978,0.0001047954,0.0001601772,0.0002506287,0.0002429121,0.001001062],"category_scores_gemma":[0.0001086107,0.00009645524,0.0002747602,0.0001146667,0.0001229976,0.0001396505,0.0001359379,0.00034115,0.0002550753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002130067,"about_ca_system_score_gemma":0.0001190149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003009255,"about_ca_topic_score_gemma":0.0004416127,"domain_scores_codex":[0.9998815,0.00002516703,0.000014537,0.00002658026,0.00003023375,0.00002192961],"domain_scores_gemma":[0.999946,0.00000933133,0.00001705991,0.000009626547,0.000008317387,0.000009592665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008490992,0.00002389058,0.00005499188,0.00002723724,0.000004257225,0.00002092869,0.000003332633,0.00005216621,0.9991667,0.0000437955,0.00003132082,0.0004864195],"study_design_scores_gemma":[0.000008113479,0.0001588151,0.0004410205,0.000002277873,0.000004557304,0.00007508069,0.000003079571,0.0004136764,0.9979416,0.00001141209,0.0009387478,0.000001757963],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929054,0.002048454,0.002798018,0.0001150791,0.00004557745,0.00004528254,0.0005201563,0.0001193091,0.001402743],"genre_scores_gemma":[0.9957454,0.0005660916,0.001582181,0.00003994082,0.000006581446,0.00003544555,0.000398007,0.00001029617,0.001616114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001001062,"threshold_uncertainty_score":0.003348887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007611330246844606,"score_gpt":0.2290372891454654,"score_spread":0.2214259588986208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}