{"id":"W4413707973","doi":"10.64628/aa.7ucahcucs","title":"Why did thalidomide’s makers ignore warnings about their drug?","year":2015,"lang":"en","type":"preprint","venue":"","topic":"Science, Research, and Medicine","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Victoria","funders":"","keywords":"Thalidomide; Drug; Business; Risk analysis (engineering); Medicine; Pharmacology; Internal medicine; Multiple myeloma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002588209,0.0005471359,0.001103607,0.0004969598,0.0001210001,0.00008619161,0.0007331477,0.0004272283,0.001675975],"category_scores_gemma":[0.001043495,0.000333522,0.0003320106,0.0003926037,0.0007386837,0.00008677713,0.0009830312,0.001836116,0.0002616277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003172933,"about_ca_system_score_gemma":0.001513922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002762754,"about_ca_topic_score_gemma":0.0002320327,"domain_scores_codex":[0.9955333,0.0001343807,0.0005714821,0.001084521,0.001723578,0.0009527691],"domain_scores_gemma":[0.9960895,0.0002012599,0.0002161647,0.001385624,0.0008083115,0.001299133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004022235,0.0001981583,0.01842609,0.0007036001,0.0002269388,0.0003203022,0.01219255,0.00001653904,0.0008616934,0.0001694517,0.9537427,0.01273973],"study_design_scores_gemma":[0.008199043,0.0006613742,0.01615254,0.003384444,0.0004235628,0.0004127817,0.01714124,0.002709478,0.004642198,0.004103964,0.9409384,0.001230964],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.649819,0.005106537,0.0005351494,0.03620604,0.003079073,0.002600722,0.00005194718,0.0006163817,0.3019851],"genre_scores_gemma":[0.855738,0.002035719,0.001137174,0.02201018,0.003034317,0.0002376897,0.0004344751,0.0001431201,0.1152293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.205919,"threshold_uncertainty_score":0.9999117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05953252543126898,"score_gpt":0.3493559192247324,"score_spread":0.2898233937934634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}