{"id":"W4413741014","doi":"10.3390/genes16091014","title":"Beyond TLR4 and Its Alternative Lipopolysaccharide (LPS) Sensing Pathways in Zebrafish","year":2025,"lang":"en","type":"review","venue":"Genes","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Zebrafish; TLR4; Lipopolysaccharide; Computational biology; Biology; Cell biology; Signal transduction; Immunology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001720507,0.0003704381,0.0003316724,0.0006009337,0.0001744349,0.0004473997,0.0002738493,0.0004149272,0.001080441],"category_scores_gemma":[0.0001072355,0.0001366656,0.0004035308,0.000252926,0.0003009717,0.0005693251,0.0002487108,0.0005538545,0.0002983348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00060816,"about_ca_system_score_gemma":0.0007191847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002928816,"about_ca_topic_score_gemma":0.00308265,"domain_scores_codex":[0.9999311,0.000007146793,0.000008112276,0.00001766359,0.00002192166,0.00001408628],"domain_scores_gemma":[0.9999647,0.000004318877,0.00001200037,0.000001261261,0.00001028023,0.000007438262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005217268,0.0000382926,0.002335053,0.009027694,0.0001212722,0.001840726,0.0003962114,0.001306378,0.7395128,0.01224391,0.005653205,0.2270027],"study_design_scores_gemma":[0.00006261544,0.001468291,0.03311893,0.001907719,0.0006236481,0.005435337,0.0005861879,0.001747133,0.1458229,0.006934372,0.8021296,0.0001633545],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.07085577,0.8977994,0.008119304,0.001616078,0.0004891071,0.00004785514,0.0006637844,0.0002226092,0.020186],"genre_scores_gemma":[0.2685801,0.6937512,0.007321809,0.001541558,0.0003313376,0.00009279662,0.0009812157,0.00004367912,0.02735636],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002928816,"threshold_uncertainty_score":0.005823553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02722533363925418,"score_gpt":0.2824289131119814,"score_spread":0.2552035794727272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}