{"id":"W4413744134","doi":"10.1186/s13287-025-04571-4","title":"Extracellular lactate improves neurogenesis by modulating H3K9 lactylation and SnoN expression under hypoxic conditions","year":2025,"lang":"en","type":"article","venue":"Stem Cell Research & Therapy","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Education and Child Care","funders":"National Natural Science Foundation of China; Natural Science Foundation of Jilin Province","keywords":"Neurogenesis; Doublecortin; Biology; Chromatin immunoprecipitation; Cell biology; Histone; Neural stem cell; Stem cell; Gene expression; Dentate gyrus; Biochemistry; Neuroscience; Gene; Hippocampus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001050722,0.0003105791,0.0003848145,0.0001569553,0.0001824974,0.0003272937,0.0001776689,0.0002155479,0.001722737],"category_scores_gemma":[0.0001065757,0.00009892418,0.0003182573,0.0001173023,0.0002374502,0.0002925871,0.0003074091,0.0005673711,0.0002157286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002957075,"about_ca_system_score_gemma":0.0003896096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009552821,"about_ca_topic_score_gemma":0.002499731,"domain_scores_codex":[0.9999019,0.000009941192,0.00001068229,0.00002499132,0.0000211203,0.00003132869],"domain_scores_gemma":[0.9999409,0.000005102458,0.00001871826,0.000003637042,0.000009866708,0.00002182307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001033389,0.0001196651,0.0007030494,0.0002525589,0.00002054091,0.00006703079,0.00003595665,0.0001239345,0.9899343,0.0001082508,0.0002261828,0.007375135],"study_design_scores_gemma":[0.0001000228,0.0009353644,0.010378,0.00003128585,0.00008050606,0.0001064154,0.0001137918,0.001151542,0.9822142,0.0001389164,0.004738275,0.0000117895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881066,0.005236982,0.003153069,0.0002621388,0.0001309365,0.00004936884,0.0007374996,0.0001503439,0.002173069],"genre_scores_gemma":[0.989875,0.002894223,0.002655956,0.0001891334,0.00002667934,0.00009588268,0.0008094111,0.00003747029,0.003416303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001722737,"threshold_uncertainty_score":0.005763054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07601849607648033,"score_gpt":0.3404500721398114,"score_spread":0.2644315760633311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}