{"id":"W4413744809","doi":"10.1111/pde.70013","title":"Early Evidence of Safety, Clinical Benefit, and Pharmacokinetics of Roflumilast Cream 0.3% Once Daily for Treatment of Mild or Moderate Plaque Psoriasis in Children Aged 2–11 Years","year":2025,"lang":"en","type":"article","venue":"Pediatric Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health","funders":"","keywords":"Medicine; Roflumilast; Plaque psoriasis; Pharmacokinetics; Dermatology; Psoriasis; Intensive care medicine; Pharmacology; Internal medicine; COPD","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002009218,0.0002276135,0.001024674,0.0003409724,0.00004700616,0.000003079647,0.0002001203,0.0003639672,0.00002538567],"category_scores_gemma":[0.0001185759,0.0001966521,0.0001732824,0.0003239071,0.000210269,0.00006140399,0.00007295993,0.00007524664,0.0000029975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002717467,"about_ca_system_score_gemma":0.0001933202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003348103,"about_ca_topic_score_gemma":0.0001458565,"domain_scores_codex":[0.9979431,0.0002835763,0.00105739,0.0003764047,0.0000382953,0.0003012558],"domain_scores_gemma":[0.9975429,0.00166552,0.0004055219,0.0002668792,0.00009051584,0.00002864827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005180274,0.0009954958,0.9773353,0.000153247,0.000557925,0.000008616188,0.0004165064,0.00003200131,0.001737789,0.0001830444,0.0003574053,0.01304236],"study_design_scores_gemma":[0.01351875,0.001126919,0.9495907,0.00007296164,0.001295099,0.00005405921,0.00004828058,0.00002284406,0.03375132,0.0001289317,0.0001984837,0.000191662],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819442,0.01641731,0.0001209181,0.0001397778,0.0003936201,0.0006815539,0.0002598216,0.00001485814,0.00002793099],"genre_scores_gemma":[0.9742244,0.02490373,0.0004809467,0.00002559713,0.00003775896,0.00006727602,0.00005581028,0.00001358054,0.0001909058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03201353,"threshold_uncertainty_score":0.801924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03145613138158878,"score_gpt":0.3160008287462838,"score_spread":0.284544697364695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}