{"id":"W4413744809","doi":"10.1111/pde.70013","title":"Early Evidence of Safety, Clinical Benefit, and Pharmacokinetics of Roflumilast Cream 0.3% Once Daily for Treatment of Mild or Moderate Plaque Psoriasis in Children Aged 2–11 Years","year":2025,"lang":"en","type":"article","venue":"Pediatric Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health","funders":"","keywords":"Medicine; Roflumilast; Plaque psoriasis; Pharmacokinetics; Dermatology; Psoriasis; Intensive care medicine; Pharmacology; Internal medicine; COPD","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001825398,0.0002391924,0.0007534031,0.0001253237,0.0001408919,0.000396503,0.0002852366,0.0005647121,0.00266347],"category_scores_gemma":[0.002543808,0.000152698,0.0005731704,0.0001725693,0.0003141875,0.0003578293,0.0001493049,0.001037831,0.0003507808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004089233,"about_ca_system_score_gemma":0.0008178023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000707607,"about_ca_topic_score_gemma":0.00238607,"domain_scores_codex":[0.9995258,0.0002365425,0.00003921125,0.00005955192,0.0000898788,0.00004914146],"domain_scores_gemma":[0.997927,0.001090371,0.0004688771,0.00007804408,0.000260078,0.0001757312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1568221,0.00782715,0.04638444,0.006825468,0.0009442011,0.001645454,0.0008876303,0.001049548,0.2381859,0.0007562338,0.009580998,0.5290908],"study_design_scores_gemma":[0.05268148,0.4051132,0.4173078,0.001967608,0.001635919,0.006140447,0.0004401007,0.001074822,0.06545971,0.0004632249,0.04761516,0.0001005215],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9560938,0.02952583,0.001269196,0.001500587,0.0001306369,0.001104686,0.002068877,0.0001192652,0.008187223],"genre_scores_gemma":[0.9838511,0.009726795,0.002054141,0.0008765974,0.0001321926,0.0002931061,0.00152907,0.00002974427,0.001507197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00266347,"threshold_uncertainty_score":0.009653687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03145613138158878,"score_gpt":0.3160008287462838,"score_spread":0.284544697364695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}