{"id":"W4413746114","doi":"10.1128/jvi.00853-25","title":"An emerging PB2-627 polymorphism increases the zoonotic risk of avian influenza virus by overcoming ANP32 host restriction in mammalian and avian hosts","year":2025,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Key Research and Development Program of China; Biotechnology and Biological Sciences Research Council; Medical Research Council Canada; National Natural Science Foundation of China","keywords":"Biology; Virology; Influenza A virus subtype H5N1; Host (biology); Virus; Avian influenza virus; H5N1 genetic structure; Influenza A virus; Genetics; Coronavirus disease 2019 (COVID-19); Infectious disease (medical specialty)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002183243,0.0003370671,0.0003090974,0.0002681971,0.0003916471,0.0004247271,0.0001610734,0.0004197349,0.001387379],"category_scores_gemma":[0.0002917,0.0001754219,0.0004550553,0.0002842693,0.0002564706,0.0002122667,0.000344925,0.0005200984,0.0004926848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002368292,"about_ca_system_score_gemma":0.0002342993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002851674,"about_ca_topic_score_gemma":0.004403904,"domain_scores_codex":[0.9998162,0.00002731479,0.00001219393,0.00005761865,0.00004596091,0.00004067246],"domain_scores_gemma":[0.9998786,0.00001828543,0.00003466327,0.00001202033,0.00002374258,0.00003263444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005386655,0.00007654334,0.09017697,0.0001373828,0.0001395676,0.0006426535,0.0001817808,0.0008089621,0.8916692,0.0005598835,0.0008115476,0.0142568],"study_design_scores_gemma":[0.0001228838,0.001104701,0.7094263,0.0001485749,0.0005337325,0.007797607,0.001122855,0.02323114,0.2296052,0.001999996,0.02480371,0.0001033616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952627,0.0005265868,0.002179909,0.0000736487,0.0000227833,0.00001500139,0.0005517403,0.00004667972,0.001320824],"genre_scores_gemma":[0.9943964,0.0001937833,0.002881655,0.000159225,0.00001234999,0.00001938159,0.001573379,0.00004193727,0.0007219424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002851674,"threshold_uncertainty_score":0.00567013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02668838987516748,"score_gpt":0.3510841457388157,"score_spread":0.3243957558636482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}