{"id":"W4413754208","doi":"10.2337/db25-0093","title":"Metabolome-Wide Mendelian Randomization and Observational Study Reveal Causal Links Between Circulating Metabolites and Youth-Onset Type 2 Diabetes","year":2025,"lang":"en","type":"article","venue":"Diabetes","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"ENRICH; Medical Research Council; Fonds de Recherche du Québec - Santé; University of Bristol","keywords":"Mendelian randomization; Metabolome; Observational study; Type 2 diabetes; Causal inference; Diabetes mellitus; Medicine; Biology; Internal medicine; Genetics; Bioinformatics; Metabolomics; Endocrinology; Genetic variants; Gene; Genotype; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005729978,0.0005088317,0.0007073754,0.0006010692,0.0004832961,0.0008669135,0.0005417812,0.0006868496,0.001742365],"category_scores_gemma":[0.01260277,0.0003262544,0.001348832,0.001111927,0.0004492508,0.0003508496,0.0006525658,0.0007047853,0.0001841909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003014441,"about_ca_system_score_gemma":0.0005218412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004226738,"about_ca_topic_score_gemma":0.00292948,"domain_scores_codex":[0.9948797,0.002846478,0.0003102744,0.001236747,0.0004440214,0.0002827803],"domain_scores_gemma":[0.9928395,0.002385126,0.001841014,0.002225497,0.0003690144,0.0003398398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003192238,0.00008832572,0.973077,0.0000800299,0.004116747,0.0006112875,0.0001482509,0.0007604026,0.003144529,0.001086676,0.001244603,0.01244985],"study_design_scores_gemma":[0.0002664503,0.0004384187,0.9858446,0.00003990076,0.001908211,0.001116587,0.0001070773,0.005816372,0.0007877092,0.001721375,0.00192709,0.00002618009],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798034,0.00143989,0.01506312,0.0003684619,0.0000793493,0.00008274378,0.002113387,0.0001502549,0.0008995292],"genre_scores_gemma":[0.9963065,0.0001793979,0.002407321,0.0001397167,0.00003469182,0.00004951935,0.0006799777,0.00002201573,0.0001809069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005729978,"threshold_uncertainty_score":0.03030336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03252650807002256,"score_gpt":0.2882092070933116,"score_spread":0.2556826990232891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}