{"id":"W4413754680","doi":"10.1016/j.jacbts.2025.04.006","title":"Novel Peptide Therapeutics Targeting the L-Type Calcium Channel Prevent Hypertrophic Cardiomyopathy by Decreasing Mitochondrial Energetics","year":2025,"lang":"en","type":"article","venue":"JACC Basic to Translational Science","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Health and Medical Research Council; Woodside; CSL Limited","keywords":"Hypertrophic cardiomyopathy; Cardiomyopathy; Medicine; Calcium; Energetics; Peptide; Calcium channel; Mitochondrion; Internal medicine; Heart failure; Cardiology; Pharmacology; Cell biology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007035601,0.0002188163,0.0003104934,0.0001605423,0.000765441,0.00007846056,0.0002947336,0.00006882734,0.000009732657],"category_scores_gemma":[0.0002286467,0.0001568921,0.000179476,0.001446358,0.0004096099,0.0001293967,0.00008145921,0.0002194023,0.000007779321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001132131,"about_ca_system_score_gemma":0.0006069011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000999115,"about_ca_topic_score_gemma":0.000009920862,"domain_scores_codex":[0.9978079,0.00004971102,0.0003416265,0.0005004593,0.0008366901,0.0004636682],"domain_scores_gemma":[0.9988716,0.0002197948,0.00005652309,0.0003104839,0.0003922248,0.0001493294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004132866,0.0002303364,0.002683592,0.00004631764,0.0001671055,0.000006993034,0.002381468,0.001870048,0.9784084,0.002422229,0.0033205,0.008049738],"study_design_scores_gemma":[0.008252337,0.0009751429,0.2486168,0.001153334,0.002491527,0.0003574455,0.002671146,0.01612017,0.2345369,0.003452023,0.479265,0.002108078],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8055765,0.006388596,0.1415519,0.03401755,0.003865696,0.001708246,0.0000920247,0.0001527715,0.006646711],"genre_scores_gemma":[0.990024,0.00007907593,0.00605071,0.002624268,0.0005576196,0.00004460352,0.00001551625,0.00001611434,0.0005880435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7438715,"threshold_uncertainty_score":0.6397872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02598226520959106,"score_gpt":0.2933656208827319,"score_spread":0.2673833556731409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}