{"id":"W4413758115","doi":"10.1101/2025.08.22.671863","title":"The C-terminal ZZ domain of the Drosophila ORB2 RNA-binding protein is required for spermatid individualization","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Vector-Borne Animal Diseases","field":"Agricultural and Biological Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Terminal (telecommunication); Spermatid; Drosophila (subgenus); Cell biology; Domain (mathematical analysis); RNA-binding protein; Drosophila melanogaster; RNA; Genetics; Biology; Computational biology; Computer science; Telecommunications; Gene; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006490989,0.0004156867,0.0004148955,0.00003842028,0.0007124217,0.0003005594,0.001331061,0.0003576752,0.00003896433],"category_scores_gemma":[0.0004267468,0.0001636306,0.0003505801,0.0007069685,0.0002197442,0.0001373795,0.0007449968,0.0003052505,0.000008039508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000131845,"about_ca_system_score_gemma":0.0002296853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005094836,"about_ca_topic_score_gemma":0.00002027301,"domain_scores_codex":[0.9974701,0.0002506575,0.0006390259,0.0006655385,0.0004974564,0.0004772021],"domain_scores_gemma":[0.9980414,0.0002233706,0.0007435241,0.0004431102,0.0004300031,0.0001186265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000565142,0.00008706252,0.003280986,0.0002534018,0.00008617586,0.000002930487,0.00001677258,0.000002186988,0.9926288,0.002957799,0.0006072325,0.00002017189],"study_design_scores_gemma":[0.0004048266,0.0001716608,0.2973159,0.001385932,0.0002145638,2.863403e-8,0.00003437126,0.0001026276,0.6838483,0.0001764055,0.01555648,0.0007888637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928728,0.0004707153,0.00001921654,0.001686296,0.0004381097,0.002172801,0.002208079,0.0001133884,0.00001856614],"genre_scores_gemma":[0.998363,0.00007231958,0.0003919443,0.0002113429,0.0003989415,0.0005042322,0.00000236431,0.000007874702,0.00004801301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3087805,"threshold_uncertainty_score":0.6672664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02172932310153913,"score_gpt":0.2307059635872432,"score_spread":0.2089766404857041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}